Parathyroid Hormone (PTH) : Definition, Test, Risks, & Evaluating
Parathyroid hormone (PTH), also called parathormone or parathyrin, is a hormone that passes through parathyroid glands which is important in bone remodeling, an ongoing process in which bone tissues are alternately restored and Over time, it is renovated. PTH is secreted in response to low blood serum calcium (Ca2 +) level. PET indirectly stimulates osteoclast activity within the bone marrow, in an attempt to release more ionic calcium (Ca2 +) in the blood to increase serum calcium levels. Bones (metaphor) act as “bank of calcium”, in which the body can “clear” to keep the amount of calcium in the blood at the appropriate level despite the current challenges of metabolic, stress and nutritious diversity. . To remove calcium, PTH is “a key that opens the bank vault”. As a result, PTH is important for health, and health problems that produce very little or too many PTH (such as hypoparathyroidism, hyperparathyroidism, or paraneoplastic syndromes) can eliminate destruction in the form of bone disease, hypocalcaemia, and hypercalcaemia.
PHT is secreted by the main cells of the Parathyroid glands as a polypeptide, which contains 84 amino acids, which is a prohormone; effective hormone-receptor interaction requires absolutely 34-N-terminal amino acids. (Data indicates that the PHT is also hidden in small amounts from the brain and thymus.) While PTH works to increase the concentration of ionic calcium (Ca2 +) in the blood, calcitonin, produced by parafollicular cells (C cells) Hormone acts to reduce the thyroid gland, the ionic calcium concentration. The PHT essentially works on the hemorrhoid hormone 1 receptor to increase the concentration of calcium in the blood, which is present at high levels in bone and kidney, and Parathyroid hormone 2 receptor, which is at high level in the central nervous system Present, pancreas, test, and placenta PTH Half Life is about 4 minutes. There is a molecular mass around 9500 DA. Parathyroid hormone passes through parathyroid glands and blood is the most important regulator of calcium levels.
What is Parathyroid Hormone?
Parathyroid hormone is hidden from four parathyroid glands, which are small glands in the neck located behind the thyroid gland. Parathyroid hormones control the levels of calcium in the blood, increasing the levels at a large scale, when they are very low. It carries on the kidneys, bones and intestines through its functions:
1. Bones – parathyroid hormones stimulate the release of calcium from the large calcium stores in the blood pressure in the bones. It enhances the destruction of bone and reduces the formation of new bone.
2. Kidney – parathyroid hormone reduces calcium deficiency in urine. Parathyroid hormone also stimulates the production of active vitamin D in the kidneys.
3. Intestine – parathyroid hormone indirectly enhances calcium absorption from food in the intestine through its effect on vitamin D metabolism.
How is Parathyroid Hormone Controlled?
Parathyroid hormone is mainly controlled by parathyroid glands by negative feedback of the calcium level in the blood. Low calcium levels in the blood stimulate the parathyroid hormone secretion, while high calcium level in the blood prevents the release of parathyroid hormones.
What Happens if I Have Too Many Parathyroid Hormones?
A primary problem in the parathyroid glands, the production of excessive parathyroid hormones increases the level of calcium in the blood ( hypercalcaemia) and is called primary hyperparathyroidism. There is a similar but very rare condition called tertiary hyperparathyroidism, which causes hypercalcaemia due to the production of extra parathyroid hormones on the previous drop of all four glands that become exacerbated. Secondary hyperparathyroidism occurs in response to low blood calcium levels and is caused by other mechanisms, for example, kidney disease and vitamin D deficiency.
Minor primary Hyperparathyroidism often causes some symptoms and is often diagnosed by finding high calcium concentration on regular blood tests. Treatment can be done by removing the surgical removal of the affected gland (parathyroidectomy). For each condition, more information on symptoms can be found in individual articles.
What Happens if I Have Very Little Parathyroid Hormones?
Very little parathyroid hormone or hypoparathyroidism, is a rare medical condition. The result may be low level of calcium in the blood (hypocalcaemia). Medically treated with oral calcium and vitamin D conformity, but the availability of parathyroid hormone replacement therapy may change the approach of treating some patients.