Hydrocodone Combination Products-Uses-side effects-dosage-interactions and Review

Why is this drug recommended?

There are products that combine hydrocodone with additional substances, and they are prescribed for various purposes. To treat moderate to severe pain, several hydrocodone combination medications are utilised. To treat coughs, other hydrocodone combination medications are employed. In addition to being an antitussive, hydrocodone belongs to the group of drugs known as opiate (narcotic) analgesics. By altering how the brain and nerve system react to pain, hydrocodone reduces pain. By reducing activity in the area of the brain that triggers coughing, hydrocodone reduces coughing.

Although you will combine hydrocodone with at least one additional drug, this monograph exclusively covers hydrocodone. Make careful to read the contents list for the hydrocodone product you are using. If you have any inquiries, speak with your physician or pharmacist.

Hydrocodone Combination Products-Uses-side effects-dosage-interactions and Review

How is this medication to be taken?

Products containing a mixture of hydrocodone are available as tablets, capsules, syrup, solutions (clear liquids), extended-release (long-acting) capsules, and extended-release (long-acting) suspensions (liquids). Typically, every 4 to 6 hours, depending on necessity, the pill, capsule, syrup, and solution are consumed. It is typical to take the extended-release capsule or suspension every 12 hours as needed. If you regularly use hydrocodone, try to take it at around the same time each day. Ask your doctor or chemist to clarify any instructions on your prescription label that you are unsure about following.

Do not break, chew, or crush the extended-release capsules; instead, swallow them whole.

Before each usage, thoroughly shake the extended-release suspension to evenly distribute the medicine. The extended-release suspension should not be used with other drugs or fluids, such as water.

Do not use a household teaspoon to measure your dose of hydrocodone combination solution, syrup, or extended-release suspension. Household teaspoons are not reliable measurement equipment, and you may receive too much or too little medication if you measure your dose with one. Use a properly designated measurement equipment, such as a dropper, medication spoon, or oral syringe, instead. If you need assistance obtaining or using a measuring equipment, see your doctor or chemist.

If the hydrocodone combo medicine you are taking is not controlling your symptoms, contact your doctor. Do not raise your medicine dose on your own. If you take extra medicine or your doctor’s prescription, you may have a deadly overdose.

If you have been using a hydrocodone combination medicine for many weeks or longer, do not discontinue taking it without first consulting your doctor. You may have withdrawal symptoms if you abruptly stop using a hydrocodone combo medication. Your doctor will most likely progressively reduce your dose.

For some hydrocodone combination medicines, ask your chemist or doctor for a copy of the manufacturer’s information for the patient.

Other use for this medication

This drug may also be recommended for other purposes; consult your doctor or chemist for additional details.

What further measures should I take?

Tell your doctor and chemist if you are allergic to hydrocodone, the other medication in the hydrocodone combination product you are taking, other opiate (narcotic) medications such as morphine or codeine, any other medications, or any of the ingredients in the hydrocodone combination product you are taking before taking it. For a list of the chemicals, see your chemist or the manufacturer’s information for the patient.
Inform your doctor and chemist about any prescription and over-the-counter drugs, vitamins, nutritional supplements, and herbal items you are taking or intend to use. Make sure you include any of the following: Antidepressants, antihistamines, and antipsychotics (medicine for mental disorders) are all examples of antidepressants. cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); ipratropium (Atrovent); lithium (Lithobid); medications for irritable bowel disease, motion sickness, Parkinson’s disease, seizures, ulcers, or urinary problems; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatript,
fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); tramadol, trazodone (Oleptro); and tricyclic antidepressants (‘mood elevators’) such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Also tell your doctor or pharmacist if you are taking or receiving monoamine oxidase (MAO) inhibitors or have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Many other medications may also interact with hydrocodone combination products, so be sure to tell your doctor about all the medications you are taking, even if they are not on this list. Your doctor may need to adjust the dosage of your drugs or closely monitor you for adverse effects.

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Inform your doctor about any herbal supplements you are taking, particularly St. John’s wort and tryptophan.
Inform your doctor if you have or have ever had any of the disorders listed in the IMPORTANT WARNING section, or if you have paralytic ileus (a condition in which digested food does not pass through the intestines). Your doctor may advise you against taking a hydrocodone combo product.
If you have or have ever had difficulties urinating, seizures, or thyroid, intestinal, liver, pancreatic, gallbladder, or renal illness, notify your doctor.
If you are nursing, inform your doctor.
You should be aware that this medicine may reduce fertility in both men and women. Discuss the dangers of using a hydrocodone combo product with your doctor.
Tell your doctor or dentist if you are about to have surgery, including dental surgery, that you are taking a hydrocodone combination medication.
You should be aware that hydrocodone combo products may cause drowsiness. Do not drive or operate machinery until you have determined how this drug affects you.

What dietary restrictions should I observe?

Continue to eat normally unless your doctor instructs you differently.

What should I do if I forget to take a medication?

This drug is typically given only when necessary. If your doctor has prescribed a hydrocodone combination medication, take the missing dosage as soon as you recall it. Wait at least 4 hours before taking the next dosage of tablets, syrup, pill, or solution, or at least 12 hours before taking the following dose of extended-release capsules or extended-release solution. If your next dosage is approaching, omit the missing dose and resume your usual dosing regimen. Do not duplicate the dose to make up for a missing one.

What are the potential Side effects of this medication?

Side effects from hydrocodone combination products are possible. Inform your doctor if any of the following symptoms are severe or persistent:
hazy thinking
unusually cheerful or unusually sad mood
trouble with dry throat urinating
itching rash
pupil constriction (black rings in the centre of the eyes)
Some of the negative effects might be severe. If you develop any of the following symptoms, contact your doctor immediately or seek emergency medical attention:
agitation, hallucinations (seeing or hearing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, loss of appetite, weakness, or dizziness
inability to get or keep an erection
irregular menstruation
decreased sexual desire
chest tightness
Other negative effects of hydrocodone combo products are possible. If you have any odd side effects while taking this medicine, contact your doctor.

If you have a significant adverse event, you or your doctor can report it to the FDA’s MedWatch Adverse Event Reporting programme online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about this medication’s storage and disposal?

Keep this medication in its original container, properly closed, and out of the reach of children. It should be stored at room temperature, away from excessive heat and moisture (not in the bathroom). Any old or no longer needed medication must be disposed of immediately through a medicine take-back programme. If you do not have a local or easily accessible take-back programme, flush any obsolete or no longer needed hydrocodone combo goods down the toilet so that others do not take them. Consult your chemist on how to properly dispose of your medicine.

It is critical to keep all medicine out of children’s sight and access since many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are readily opened by young children. To keep small children safe from poisoning, always lock the safety caps and immediately store the medication in a safe location out of their sight and reach. http://www.upandaway.org

In the event of an emergency or an overdose

In the event of an overdose, dial 1-800-222-1222 for poison control. There is additional information accessible online at https://www.poisonhelp.org/help. If the person has collapsed, had a seizure, is having difficulty breathing, or cannot be woken, dial 911 immediately.

While using a hydrocodone combination product, talk to your doctor about keeping a rescue drug called naloxone on hand (e.g., at home or the workplace). Naloxone is used to counteract the potentially fatal consequences of an overdose. It relieves hazardous symptoms produced by excessive levels of opiates in the blood by inhibiting the effects of opiates.

If you live in a household with small children or someone who has misused street or prescription drugs, your doctor may also prescribe naloxone. Make sure you and your family members, carers, or anyone who spend time with you understand how to recognise an overdose, how to administer naloxone, and what to do until emergency medical aid comes. Your doctor or chemist will demonstrate how to use the drug to you and your family members. Request the instructions from your chemist or go to the manufacturer’s website.

If you experience overdose symptoms, a friend or family member should provide the first dosage of naloxone, contact 911 immediately, then stay with you and closely monitor you until emergency medical aid comes. After receiving naloxone, your symptoms may return within a few minutes. If your symptoms reappear, the individual should provide another dosage of naloxone. If symptoms reappear before medical aid comes, further doses may be administered every 2 to 3 minutes.

Overdose symptoms may include the following:
pupils that have been constricted or enlarged
slow, shallow, or no breathing trouble breathing slow, shallow, or no heartbeat
skin that is chilly, clammy, or bluish
extreme drowsiness
convulsions that are unable to respond or awaken

What else should I be aware of?

Keep all of your doctor’s and laboratory appointments. Your doctor will request lab testing to determine your body’s reaction to a hydrocodone combo product.

Tell your doctor and the laboratory professionals that you are taking hydrocodone before undergoing any laboratory tests (particularly those involving methylene blue).

This prescription cannot be renewed. Call your doctor if you still have discomfort or a cough after you’ve finished your medicine.

It is critical that you keep a written record of all prescription and nonprescription (over-the-counter) medications you are taking, as well as any vitamins, minerals, or other dietary supplements. You should carry this list with you whenever you go to the doctor or are admitted to the hospital. It is also crucial to have this information on hand in case of an emergency.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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