Sinemet Oral : Uses, Side Effects, Interactions

Sinemet 10-100

GENERIC NAME(S): Carbidopa-Levodopa


This combination drug is used to treat symptoms like Parkinson’s disease or Parkinson (such as stiffness, hardness, difficulty in walking). It is believed that Parkinson’s disease is due to very small amounts of naturally occurring substances (dopamine) in the brain. Levodopa turns into dopamine in the brain, which helps to control movement. Carbidopa prevents breakdown of the levodopa in the bloodstream, so more lavodopa can enter the brain. Carbidopa can also reduce some effects of levodopa such as nausea and vomiting.

How to use Sinemet 10-100

Take Sinemet with or without mouth directed by your doctor, usually 3 to 4 times a day.

Taking this medicine with food can help to reduce nausea. Avoiding a high-protein diet is best (it reduces the amount of levodopa in your body) unless it is directed by your doctor. Separate your dose of this drug as much as possible from any iron supplements or products containing iron (such as multivitamin with minerals). Iron can reduce the amount of this drug absorbed by the body. Contact your doctor or pharmacist for more information.

Dosage is based on your medical condition and treatment response. To reduce your risk of side effects, your doctor may direct you to start this medication on low dose and gradually increase your dose. Follow your doctor’s instructions carefully. This combination drug comes in different strengths with different doses of carbidopa and levodopa in each tablet. Make sure you have the right strength of both medicines. Your doctor can write Carbidopa alone to take this combination.

Use Sinemet regularly to get the most benefit. To help you remember, take it every day at the same time.

Due to the next dose, some patients may experience “wearing-off” (worsening of symptoms). There may also be an “on-off” effect, in which there is a sudden short-term rigidity. If these effects occur, contact your doctor for potential dose adjustments that may help in reducing this effect.

Do not stop taking Sinemet without consultation with your doctor. When this medicine gets reduced or suddenly stops, some conditions may get worse. Your dosage may need to be gradually reduced. (See also Side Effects section.)

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Dizziness, nervousness, nausea, vomiting, loss of appetite, sleepiness, abnormal dreams or headache can occur. If any of these effects persists or worsens, tell your doctor or pharmacist immediately.

Sinemet can cause saliva, urine, or sweat which transforms a darker color. This effect is harmless, but your clothes can stain.

To reduce the risk of dizziness and lighthouse, slowly rise while sitting or lying down from the position of lying.

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Some people taking Sinemet have suddenly slept during their normal daily activities (such as talking on the phone, driving). In some cases, sleep has already happened without feelings of sleepiness. This sleeping effect can occur at any time during treatment with carbidopa / levodopa, even if you have used this medicine for a long time. If you experience sleep increase in the daytime or fall asleep, do not drive or do other potentially dangerous activities unless you have discussed this effect with your doctor. Your risk of the effect of this sleep increases with the use of alcohol or other medicines that can make you dull. See also the Precautions section.

Tell your doctor immediately if you have a serious side effect, including: You can not control the new / worsening movements / cramping, enlarged eye blink / twisting, unconsciousness, changes in vision (e.g blurred vision, double vision ), Severe stomach / stomach ache, black / terry stool, vomiting that looks like coffee grounds, changes in mental / mood (such as movement, hallucinations, depression, thoughts of suicide ), Sign of infection (such as sore throat which is not removed), easy bleeding / injury, abnormal fatigue, hands / feet tingling, unusual strong insistence (such as increase in gambling, sexual urges)

If you have a very serious side effect, get medical help, including: chest pain.

Pausing or reducing the dosage of Sinemet can rarely be a very serious condition, which is called neuroleptic malignant syndrome (NMS). If you have any of the following symptoms, seek medical help immediately: fever, abnormal muscle stiffness, severe confusion, sweating, fast / irregular heart beat, sharp breathing.

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking Sinemet, tell your doctor or pharmacist whether you are allergic to carbidopa or levodopa; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using this drug, tell your doctor or pharmacist your medical history, especially: liver disease, glaucoma, respiratory problems (such as asthma), heart disease (such as heart attack, irregular heart beat) Kidney disease, stomach / intestinal ulcer, mental / mood disorders (such as depression, schizophrenia), blood disorders, seizures, sleep disorders

Sinemet may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution. Limit alcoholic beverages. If you are using marijuana, talk to your doctor. See also the Side Effects section.

Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).

During pregnancy, Sinemet should be used only when it is clearly necessary. Discuss the risks and benefits with your doctor.

Levodopa passes through breast milk. It is unknown if carbidopa passes in breast milk. Consult your doctor before breastfeeding.


Also see how to use the section.

Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that can interact with this drug include: Antipsychotic drugs (such as chlorpromazine, haloperidol, thioridazine), certain drugs used to treat high blood pressure (such as methyldopa).

Taking the MAO inhibitor with Sinemet can be a cause of serious (potentially fatal) drug interactions. Avoid taking the MAO inhibitor (Isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, tranylcypromine) during treatment with this drug. Most of the Mao blockers should not be taken for two weeks before treatment with this drug. However, some MAO inhibitors (rasagiline, safinamide, selegiline) ​​can be used with careful monitoring by your doctor. Ask your doctor when to start or stop this medication.

Sinemet can interfere with some laboratory tests (including urine catecholamine/glucose/ketone tests), probably producing incorrect test results. Ensure that the lab staff and all your doctors know that you use this medicine.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, irregular heartbeats, changes in mental / mood (such as movement).


Do not share this medication with others.

Labs and / or medical tests (such as cardiovascular / kidney / liver function, complete blood count) should be done periodically to monitor your progress or examine side-effects. Consult your doctor for more details.

People with Parkinson’s disease can increase the risk of developing skin cancer (melanoma). Tell your doctor immediately if you have a sesame that grows or looks different, or if you have other unusual skin changes. Ask your doctor if your skin should be checked regularly.

Missed Dose

If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis supplement and start your normal dose program again. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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