Safinamide : Uses, Side Effects, Interactions
Safinamide is used with another drug (levodopa/carbidopa) to treat symptoms of Parkinson’s disease. It can help improve symptoms such as closeness, hardness and difficulty moving. It can also help reduce the amount of “off” time (slow speed or duration of immobility).
Safinamide belongs to a class of drugs known as MAO inhibitors. It works by increasing the level of some natural substances (such as dopamine) in the brain. It is believed that Parkinson’s disease is due to very low dopamine in the brain.
How To Use Safinamide
If you start taking Safinamide from your pharmacist and you get a refill every time, then please read the Patient Information Letter. If you have any questions, ask your doctor or pharmacist.
Directly medicate this medicine with your mouth or without food, usually daily once.
Dosage is based on your medical condition and treatment response. Do not increase your dose or take it more than it has been fixed. There will be no improvement in your situation, and the risk of your side effects will increase.
Use this drug regularly to get the most benefit. To help you remember, take it at the same time every day.
Do not stop taking this medicine without consultation with your doctor. When this medicine suddenly stops, some conditions may get worse. Your dose may need to be gradually decreased.
The reaction of very serious hypertension can rarely occur if you eat Safinamide and eat tyramine in large quantities for 2 weeks after it is stopped. Avoid foods that are high in tyramine, such as old things (such as Stilton cheese). Consult with your doctor or dietician what foods you should avoid and if you do not feel good after eating or drinking some foods while taking this medicine. See also the Side Effects section.
Tell your doctor if this medicine stops working well or if your condition worsens.
Dizziness or drowsiness may occur. If any of these effects remains or gets worse, then tell your doctor or pharmacist immediately.
To reduce the risk of dizziness and lighthouse, slowly rise while sitting or lying down, especially when you start taking Safinamide for the first time.
Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.
Tell your doctor immediately if you have a serious side effect, including: unconsciousness, loss of balance, changes in mental / mood (such as anxiety, movement, hallucinations), deterioration of deteriorating muscles / twitch / uncontrollable movements, abnormal strong insistence (e.g. ) Increase in gambling, sexual urges increased).
Some people taking safinamide have suddenly slept during their usual daily activities (such as talking on the phone, driving). In some cases, sleep has already happened without feelings of sleepiness. This sleep effect may occur at any time during treatment with safinamide, even if you have used this medicine for a long time. If you experience an increase in sleep during the day or fall asleep, do not drive or participate in other potentially dangerous activities, unless you have discussed this effect with your doctor. Your risk of the effect of this sleep increases with the use of alcohol or other medicines that can make you dull. See also the Precautions section.
This drug can increase serotonin and rarely cause a very serious condition, which is called serotonin syndrome / toxicity. The risk increases if you are taking other medicines which increase the serotonin, so tell your doctor or pharmacist about all the medicines that you take. Get medical help immediately when some of the following symptoms develop: Fast heartbeats, hallucinations, loss of coordination, severe dizziness, severe nausea / vomiting / diarrhea, muscle shaking, unexplained fever, abnormal movement or restlessness
Safinamide can rarely cause the attack of hypertension (high blood pressure), which can be fatal. Many drug and food interactions can increase this risk (see how to use and drug interaction section). If any of these have serious side effects, seek medical help immediately: severe headache, fast / slow / irregular / fast heartbeat, chest pain, neck / cramps, severe nausea / vomiting, sweating / smelly skin (sometimes- Occasionally due to fever), broad pupils, vision changes (such as double / blurred vision), sudden sensitivity towards light (photophobia)
A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.
In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.
Before taking Safinamide, tell your doctor or pharmacist whether you are allergic to it; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.
Before using this drug, tell your doctor or pharmacist your medical history, especially: liver disease, high blood pressure, mental / mood disorders (such as schizophrenia, bipolar disorder, depression), eye problems (such as macular degeneration, uveitis), sleep disorders.
Safinamide can make you passable or dizzy. Alcohol or marijuana (cannabis) can make you more damp or dizzy. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). See also the Side Effects section.
Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).
During pregnancy, Safinamide should be used only when it is clearly necessary. Discuss the risks and benefits with your doctor.
It is unknown if this medicine passes in breast milk. Consult your doctor before breastfeeding.
If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center.
Do not share this medication with others.
Labs and / or medical tests (such as blood pressure, liver function) should be done when you are taking this medication. Keep all medical and lab appointments.
People with Parkinson’s disease can increase the risk of developing skin cancer (melanoma). Tell your doctor immediately if you have a mole that grows or looks different, or if you have any other unusual skin changes. Ask your doctor if your skin should be checked regularly.
If you miss a dose, then leave the missed dose. Take your next dose at regular times. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.
Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.
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Hey, how’s it going?
I want to pass along some very important news that everyone needs to hear!
In December of 2017, Donald Trump made history by recognizing Jerusalem as the capital of Israel. Why is this big news? Because by this the Jewish people of Israel are now able to press forward in bringing about the Third Temple prophesied in the Bible.
Jewish Rabbis have publicly announced that their Messiah will be revealed in the coming years who will be a leader and spiritual guide to all nations, gathering all religions under the worship of one God.
Biblical prophecy tells us that this Jewish Messiah who will take the stage will be the antichrist “who opposes and exalts himself above all that is called God or that is worshiped, so that he sits as God in the temple of God, showing himself that he is God” (2 Thessalonians 2:4). For a time he will bring about a false peace, but “Therefore when you see the ‘abomination of desolation,’ spoken of by Daniel the prophet, standing in the holy place (Matthew 24:15)…then there will be great tribulation, such as has not been since the beginning of the world until this time, no, nor ever shall be” (Matthew 24:21).
More importantly, the power that runs the world wants to put a RFID microchip in our body making us total slaves to them. This chip matches perfectly with the Mark of the Beast in the Bible, more specifically in Revelation 13:16-18:
“He causes all, both small and great, rich and poor, free and slave, to receive a mark on their right hand or on their foreheads, and that no one may buy or sell except one who has the mark or the name of the beast, or the number of his name.
Here is wisdom. Let him who has understanding calculate the number of the beast, for it is the number of a man: His number is 666.”
Referring to the last days, this could only be speaking of a cashless society, which we have yet to see, but are heading towards. Otherwise, we could still buy or sell without the mark amongst others if physical money was still currency. This Mark couldn’t be spiritual because the word references two different physical locations. If it was spiritual it would just say in the forehead. RFID microchip implant technology will be the future of a one world cashless society containing digital currency. It will be implanted in the right-hand or the forehead, and we cannot buy or sell without it. Revelation 13:11-18 tells us that a false prophet will arise on the world scene doing miracles before men, deceiving them to receive this Mark. Do not be deceived! We must grow strong in Jesus. AT ALL COSTS, DO NOT TAKE IT!
“Then a third angel followed them, saying with a loud voice, “If anyone worships the beast and his image, and receives his mark on his forehead or on his hand, he himself shall also drink of the wine of the wrath of God, which is poured out full strength into the cup of His indignation. He shall be tormented with fire and brimstone in the presence of the holy angels and in the presence of the Lamb. And the smoke of their torment ascends forever and ever; and they have no rest day or night, who worship the beast and his image, and whoever receives the mark of his name” (Revelation 14:9-11).
People have been saying the end is coming for many years, but we needed two key things. One, the Third Temple, and two, the technology for a cashless society to fulfill the prophecy of the Mark of the Beast.
Visit http://WWW.BIBLEFREEDOM.COM to see proof for these things and why the Bible truly is the word of God!
If you haven’t already, it is time to seek God with all your heart. Jesus loves you more than you could imagine. He wants to have a relationship with you and redeem you from your sins. Turn to Him and repent while there is still hope! This is forever…God bless!
“EITHER HUMAN INTELLIGENCE ULTIMATELY OWES ITS ORIGIN TO MINDLESS MATTER OR THERE IS A CREATOR…” – JOHN LENNOX
We all know God exists. Why? Because without Him, we couldn’t prove anything at all. Do we live our lives as if we cannot know anything? No. So why is God necessary? In order to know anything for certain, you would have to know everything, or have revelation from somebody who does. Who is capable of knowing everything? God. So to know anything, you would have to be God, or know God.
A worldview without God cannot account for the uniformity and intelligibility of nature. And why is it that we can even reason that God is the best explanation for this if there is no God? We are given reason to know or reject God, but never to know that He does not exist.
It has been calculated by Roger Penrose that the odds of the initial conditions for the big bang to produce the universe that we see to be a number so big, that we could put a zero on every particle in the universe, and even that would not be enough to use every zero. What are the odds that God created the universe? Odds are no such thing. Who of you would gamble your life on one coin flip?
Is there evidence that the Bible is the truth? Yes. Did you know that the creation accounts listed in the book of Genesis are not only all correct, but are also in the correct chronological order? That the Bible doesn’t say the Earth was formed in six 24-hour days but rather six long but finite periods of time? That the Bible makes 10 times more creation claims than all major “holy” books combined with no contradictions, while these other books have errors in them? The Bible stood alone by concurring with the big bang saying, “In the beginning God created the heaven and the earth” (Genesis 1:1); and says our universe is expanding, thousands of years before scientists discovered these things. Watch a potential life-changing video on the front page of http://WWW.BIBLEFREEDOM.COM with Astronomer(PhD) Hugh Ross explaining all these facts based on published scientific data. He has authored many books, backed even by atheist scientists.
Jesus fulfilled more than 300 Messianic prophecies concerning His birth place, details of His life, His mission, His nature, His death, and His resurrection. He came to pay a debt that we could not, to be our legal justifier to reconcile us back to a Holy God; only if we are willing to receive Him: “For the wages of sin is death, but the gift of God is eternal life in Christ Jesus our Lord” (Romans 6:23).
God so loved the world that He gave us His only begotten son, so that whoever believes in Him, through faith, shall not perish, but have everlasting life. Jesus says if we wish to enter into life to keep the commands! The two greatest commands are to love God with all your heart, soul, strength, and mind; and your neighbor as yourself. All the law hang on these commands. We must be born of and lead by the Holy Spirit, to be called children of God, to inherit the kingdom. If we are willing to humble ourselves in prayer to Jesus, to confess and forsake our sins, He is willing to give the Holy Spirit to those who keep asking of Him; giving us a new heart, leading us into all truth!
Jesus came to free us from the bondage of sin. The everlasting fire was prepared for the devil and his angels due to disobedience to God’s law. If we do the same, what makes us any different than the devil? Jesus says unless we repent, we shall perish. We must walk in the Spirit, producing fruits of love and forgiveness, so we may not fulfill the lusts of the flesh being hatred, fornication, drunkenness and the like. Whoever practices such things will not inherit the kingdom (Galatians 5:16-26). If we sin, we may come before Jesus to ask for forgiveness (1 John 2:1-2). Evil thoughts are not sins, but rather temptations. It is not until these thoughts conceive and give birth by our hearts desire that they become sin (James 1:12-15). When we sin, we become in the likeness of the devil’s image, for he who sins is of the devil (1 John 3:8); but if we obey Jesus, in the image of God. For without holiness, we shall not see the Lord (Hebrews 12:14).
The oldest religion in the world is holiness (James 1:27). What religion did Adam and Eve follow before the fall? Jesus, Who became the last Adam, what religion does He follow? Is He not holy? He never told us to follow any religion or denomination but to deny ourselves, take up our cross daily, and follow Him (Luke 9:23). There are many false doctrines being taught leading people astray. This is why we need the Holy Spirit for discernment. Unlike religion, holiness cannot be created. It is given to us from above by the baptism of the Spirit. Jesus is more than a religion; He is about having a personal relationship with the Father. Start by reading the Gospel of Matthew, to hear the words of God, to know His character and commandments. Follow and obey Jesus, for He is the way, the truth, and the life!