Promethazine Oral : Uses, Side Effects, Interactions


Chemical Names: Promethazine; Proazamine; Diphergan; Phenargan; Phensedyl; Promazinamide
Molecular Formula: C17H20N2S
Molecular Weight: 284.421 g/mol
Safety Summary: Laboratory Chemical Safety Summary (LCSS)

Promethezine histamine is a phenothiazine derived with H-1 blocker, antimuscarinic and sedan properties. It is used as a antiallergic, in pruritus, for speed disorder and fainting, and also in animals.

Promethezine is a phenothiazine containing antiemetic and antihistamine properties. Promethezine histamine opposes the central and peripheral effects of histamine mediated by H1 receptors. The effects include spasmodic contraction of bronchoconstriction, vasodilation and gastrointestinal smooth muscles. Apart from this, this agent binds to the muscarinic receptors, which results in anticholinergic and antiemetic activities.

Promethezine is the first generation of antihistamine that is related to phenothiazine class and is mainly used as an antiemetic to prevent nausea and vomiting treatment and motion sickness. Regardless of its phenothiazine structure, Promethezine has not been linked to the diagnosis of clear acute liver injury.

Why is this Medication Prescribed?

Promethezine use allergic reactions such as allergic rhinitis (allergic reactions due to runny nose and pollen, mold or dust), allergic conjunctivitis (red allergic reactions due to water), allergic skin reactions and allergic reactions relief Is used to give. For blood or plasma products. Promethezine is used with other medicines to cure sneezing, coughing, and runny nose such as anaphylaxis (sudden, severe allergic reactions) and symptoms of common cold. Promethezine is used to relax and fain before and after surgery, during labor and other times. The use of Promethezine is also used to prevent and control nausea and vomiting, which can occur after surgery, and helps with the removal of pain after surgery with other drugs. The use of Promethezine is also used to prevent and treat motion sickness. Prometheus helps in controlling symptoms, but will not treat symptoms due to symptoms or recovery of speed. Promethezine is in a class of medicines called phenothiaszines. It works by blocking the action of a certain natural substance in the body.

How should this Medicine be used?

Promethezine comes in the form of a tablet and a suppository to take it as a syrup (mouth) and use a rectal. When Promethezine is used to treat allergies, it is usually taken daily from one to four times during meals and / or at bedtime. When Promethezine is used for relief from cold symptoms, then it is usually taken every 4 to 6 hours as needed. When Promethezine is used to treat motion sickness, then it is taken 30 to 60 minutes before the journey and after 8 to 12 hours if needed. On long trips, Promethezine is usually taken in the morning and before the evening meal every day of the journey. When Promethezine is used to prevent nausea or vomiting, it is usually taken every 4 to 6 hours as needed. Promethejne can also be taken in the night before surgery to remove anxiety and produce quiet sleep. Follow the instructions on your pamphlet carefully, and ask your doctor or pharmacist to understand any part. Take Promethezine exactly as guided. Do not take it less or more or take it more than your doctor prescribed.

Prometheus suppositories are only for anal use. Do not try to swallow suppository or to put it in another part of your body.

If you are taking Promethezine liquid, do not use domestic spoons to measure your dose. Use measuring spoons or cups that come with medicine, or use a spoon made specifically to measure the drug.

To insert the Promethezine suppository, follow these steps:
•  If suppository feels soft, then keep it in cold, running water for 1 minute. Remove the cover.
•  Dip the tip of the suppository into water.
•  Lie on your left and raise your right knee to your chest. (The person in the left hand should lie on the right and the left knee should be raised.)
•  Using your finger, insert the suppository in the rectum in the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeter) in children, at 2 years old and 1 in (2.5 centimeter) of adults. Hold it for a few moments.
•  Stand about 15 minutes later. Wash your hands thoroughly and start your normal activities again.

Other Uses for this Drug

This drug can be prescribed for other uses; Ask your doctor or pharmacist for more information.

What special Precautions should I follow?

Before taking Promethezine,

•  Tell your doctor and pharmacist whether you are allergic to Promethezine, other phenothiazines (some medicines used for the treatment of mental illnesses, nausea, vomiting, severe hiccups and other conditions) or any other medicines. Also tell to your doctor and pharmacist whether you have ever had an unusual or unexpected reaction when you took a promethazine, another promethazine, or some other medication. Ask your doctor or pharmacist if you do not know that the medication that is allergic to you is phenothiazine.
•  Tell your doctor and pharmacist what plans you are taking or taking non-prescription medicines, vitamins, nutritional supplements and herbal products or planning to take. Be sure to mention any of the following: Antidepressant (‘mood lift’) such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; azathioprine (Imuran); barbiturates such as phenobarbital (Luminal); cancer chemotherapy; epinephrine (Epipen); ipratropium (Atrovent)medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson’s disease, seizures, ulcer or urinary problems; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); Drug and other pain medicines; Sedative; Sleeping pills, and tranquilizers. Your doctor may need to change the dosage of your medications or carefully monitor for side effects.
•  Tell your doctor whether you have ever increased prostate (male reproductive gland) or not; Cataract (a condition in which the pressure in the eye increases, the gradual loss of vision can occur); Seizure; Ulcer; Obstruction in the passage between the stomach and the intestine; Bladder obstruction; Asthma or other lung disease; sleep apnea; Cancer; Any condition that affects the production of blood cells in your bone marrow; Or heart or liver disease. If you are giving promethazine to a child, then tell the child’s doctor whether the child has any of the following symptoms, before that he gets the medicine: vomiting, listening, drowsiness, illusion, aggression, Symptoms like seizures, skin pallor or eyes, weakness, or flu. Also tell the child’s doctor that if the child is not drinking normally, he or she is seen to have excessive vomiting or diarrhea, or dehydrated.
•  Tell your doctor whether you are pregnant, planning to get pregnant, or breastfeeding. If you become pregnant while taking promethazine, call your doctor.
•  Talk to your doctor about the risks and benefits of taking promethazine when you are 65 years of age or older. Older adults should not usually take promethazine because it is not as safe as other medicines which can be used to treat similar conditions.
•  If you are undergoing surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine.
•  You should know that this medication can make you feasible. Do not run a car or machinery until you know how this medicine affects you. If you are giving promethazine to a child, make sure that the child does not get hurt while participating in bike activities or other activities that may be dangerous to see.
•  When you are taking this medicine, ask your doctor about the safe use of alcohol. Alcohol can make the side effects of Prometheus worse.
•  Plan to avoid sunburn or avoid long-term contact and wear protective clothing, sunglasses and sunscreen. Prometheus can make your skin sensitive to sunlight.

What special dietary instructions should I follow?

Continue your usual diet until your doctor tells you to.

What should I do if I forget a dose?

Take missed doses as you remember. However, if it is almost time for the next dose, leave the missed dose and continue your regular diet schedule. Do not take double dose to make a mistake.

What side effects can This Medication Cause?

Promethazine can cause side effects. Tell your doctor whether any of these symptoms are serious or not far away:
•  Dry mouth
•  Sleepiness
•  Inattentiveness
•  Difficulty sleeping or sleeping
•  Bad dreams
•  Dizziness
•  Ear-ringing
•  Blurry or double vision
•  Loss of coordination
•  Nausea
•  Vomiting
•  Nervousness
•  Restlessness
•  Activism
•  Unusually happy mood
•  Filled nose
•  Itching

Some side effects can be serious. If you have any of the following symptoms, call your doctor immediately.
•  Wheezing
•  Slow breathing
•  The breath stops for a while
•  Fever
•  Sweating
•  Hard muscles
•  Vigilance decreased
•  Fast or irregular pulse or heartbeat
•  Greediness
•  Unusual or uncontrollable movements
•  Hallucinations (voices to see or hear things that do not exist)
•  Confusion
•  Heavy or unbearable fear or feeling
•  Seizure
•  Uncontrollable movement of one part of the body
•  Unusual injury or bleeding
•  Sore throat, fever, chills and other symptoms of infection
•  Uncontrolled Eye Speed
•  Tongue sticking out
•  Abdominal abnormal condition
•  Inability to respond to people around you
•  Skin or yellowing of eyes
•  Red spots
•  Hives
•  Swelling in the face, eyes, lips, tongue, throat, hands, arms, legs, ankles, or lower legs
•  Hoarseness
•  Difficulty breathing or swallowing

Promethazine may be the cause of other side effects. If you are taking this medicine, then call your doctor if you experience any unusual problem.

What should I know about the storage and disposal of this drug?

Keep this medicine in a carton or container, it tightly closes, and is out of reach of children. Keep promethazine’s pills and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Store Promethean suppository in the refrigerator. Protect the drug from light.

To ensure that pets, children, and other people can not afford them, special medicines should be disposed of inappropriately. However, you should not throw this medicine under the toilet. Instead, the best way to settle your medication is to take a medication back program. Talk to your pharmacist or contact your local garbage / recycling department to learn about take-back programs in your community.

It is important to keep all the medicines out of sight and reach of children, because many containers (such as weekly pellet brains and eye droplets, creams, patches, and inhalers) are not child-resistant and younger children can easily open them.

In case of Emergency / Overdose

In the case of overdose, call the Poison Control Helpline at 1-800-222-1222. Information is also available online at If the victim has fallen, a seizure has occurred, there is trouble in breathing, or can not be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:
•  Breathing trouble
•  Slowed down or stopped breathing
•  Dizziness
•  Affair
•  Unconsciousness
•  Fast heartbeat
•  Tight muscles that are difficult to move
•  Loss of coordination
•  Continuous twisting of hands and feet
•  Dry mouth
•  Wide pupils (black circles in between the eyes)
•  Flushing
•  Nausea
•  Constipation
•  Unusual stimulation or movement
•  Bad dreams

What other information should I know?

Keep all appointments with your doctor.

Promethazine can interfere with the results of home pregnancy tests. Talk to your doctor if you think you may be pregnant when you are taking Promethazine. Do not try to test for a pregnancy at home.

Before conducting any laboratory test, tell your doctor and laboratory personnel that you are taking Promethazine.

Do not let anyone else take your medication. Ask any questions from your pharmacist about refilling your prescription.

It is important for you to keep any of the medicines you are taking, including all the medicines and written lists of non-transcription (over-the-counter), as well as any product, such as vitamins, minerals or other dietary supplements. Every time you meet a doctor or if you are admitted to a hospital, then you should bring this list with you. It is also important information to take with you in case of emergencies.

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