Pennsaid Topical : Uses, Side Effects, Interactions

Pennsaid Solution

GENERIC NAME(S): Diclofenac Sodium


Pennsaid is used to treat arthritis of the knee(s). It reduces pain and swelling, and helps in improving your ability to move and flex the joint. Diclofenac is known as an nonsteroidal anti-inflammatory drug (NSAID).

How to use a Pennsaid

Read the medication guide and, if available, the Patient Information Catalog, before you start using Pennsaid given by your pharmacist and every time you receive refill. If you have any questions, ask your doctor or pharmacist.

Before using the pump for the first time, remove the cap and push the pump directed by the manufacturer.

Apply this medicine to clean, dry skin directed by your doctor, usually for the affected knee (s) 2 times a day. Pour the pump head firmly 2 times and place the medicine on the palm of your hand. Apply the medicine equally around the front, back and knee. If your doctor is instructed to do so, repeat for another knee. Allow the medicine to dry for several minutes. As long as the treated knee does not completely dry, do not wear clothes on it. Also, do not apply sunscreen, insect repellant, lotion, or other occasional products to your knees unless it is completely dry.

Be sure to wash your hands before and after applying the medication. Avoid taking this medicine in eyes, nose or mouth. Avoid bath / bath for at least 30 minutes after application. Do not apply on open wounds or infected or damaged skin. Unless you are instructed to do so by your doctor, then wrap, heat, or do not strip the heat on the treated area (such as a heating pad).

Use Pennsaid regularly to get the most benefit. Do not use too much, apply it more often, or use it for longer than scheduled time.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

See also the warning section.

There may be symptoms like skin irritation, dryness, redness or itching. If any of these effects persists or worsens, tell your doctor or pharmacist immediately.

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Pennsaid can increase your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor immediately if you have any serious side effects, including: signs of kidney problems (such as changes in urine volume), symptoms of heart failure (such as swelling ankle / foot, abnormal fatigue, abnormal / sudden gaining weight) ).

Pennsaid can rarely cause serious (potentially fatal) liver disease. If you have any symptoms of liver damage, immediately seek medical help, including: dark urine, continuous nausea / vomiting / loss of appetite, stomach / stomach ache, yellowing of the eyes / yellowing of the skin .

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before using Pennsaid, tell your doctor or pharmacist whether you are allergic to it; Or aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using Pennsaid, tell your doctor or pharmacist your medical history, especially: including the history of breathing with a drowsy / filled nose after taking asthma (aspirin or other NSAIDs), blood disorder (like anemia , Bleeding or clotting problems), nose (nose), heart disease (like previous heart attack), high blood pressure, liver disease, stomach / intestinal problems (such as bleeding, ulcer), increased stroke.

The use of NSAID medicines, including Pennsaid, can sometimes cause kidney problems. The probability of having problems is more if you are dehydrated, cardiac failure or kidney disease, an elderly adult, or if you take some medications (see also drug interaction section). To prevent dehydration directed by your doctor, drink plenty of fluid and tell your doctor immediately if you have a change in urine volume.

Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).

Pennsaid can cause bleeding in the stomach. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medicine can make you more sensitive to the sun. Keep your time limited in the sun. Avoid Tanning Booths and Sunlamps. Use sunscreen on the outside and wear protective clothing. Tell your doctor immediately if you have sunburned or have blisters / redness on the skin.

Older adults may be more susceptible to the side effects of this drug, especially stomach / intestinal bleeding and kidney problems.

Before using Pennsaid, women of childbirth should talk about their benefits (including miscarriage, difficulty in getting pregnant) with their doctor (s). Tell your doctor whether you are pregnant or if you are planning to get pregnant. During pregnancy, this drug should be used only when it is clearly necessary. This unborn child is not recommended to use during the first and last quarters of pregnancy due to possible damage and intervention with normal labor or delivery.

It is unknown if this form of Pennsaid passes through breast milk. Although there is no report of harm to nursing infants, but consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, “water pills” (diuretics such as furosemide).

Pennsaid can increase the risk of bleeding when it is used with other medicines, which can lead to bleeding. Examples include anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin, among others.

Carefully review all the prescription and non-prescription medication labels from the painkillers / fever reassuring agents (aspirin, NSAIDs such as ibuprofen, ketorolac, or naproxen) of many medicines. These medicines are similar to Pennsaid and if taken together, the risk of your side effects can increase. However, if your doctor has instructed you to take low-dose aspirin to prevent heart attack or stroke (usually on a diet of 81-325 mg in a day), then you should continue taking aspirin as long as Your doctor will not give you directions. Ask your doctor or pharmacist for more information.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: severe stomach ache, vomiting which looks like coffee grounds, excessive drowsiness, slow / shallow breathing, recovery.


Do not share this medication with others.

Labs and / or medical tests (such as blood pressure, complete blood count, liver and kidney function tests) can be performed periodically to monitor your progress or to examine side-effects. Consult your doctor for more details.

Non-drug treatments that are approved by your doctor for arthritis (such as if necessary for weight loss, strengthening and conditioning exercises) can help to improve your flexibility, speed limits, and joint work. Consult your doctor for specific instructions.

Missed Dose

If you are prescribed this drug at a regular time (not just “as required”) and you remember a dose, then as soon as you remember If it is near the next dose time, then leave the missed dose. Take your next dose at regular times. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed to do so, do not flush the medicines in the toilet and do not drain them. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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