Parnate Oral : Uses, Side Effects, Interactions


GENERIC NAME(S): Tranylcypromine


Tranylcypromine, sold under the trade name Parnate among others. Parnate is an antidepressant (monoamine oxidase inhibitor). This medicine treats depression by restoring the balance of some natural substances (neurotransmitters) in the brain. Parnate can improve your mood and welfare feelings. Generally, this drug is used in people who have not responded to treatment with other medicines.

How to use Parnate

Before starting Parnate or Tranylcypromine, read the medication guide available from your pharmacist and every time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medicine from the mouth, usually in divided doses or by your doctor. This medicine can be taken with or without food. Dosage is based on your medical condition and medical reaction and will generally not exceed 60 milligrams per day.

To reduce your risk of side effects, your doctor may start you at low doses and gradually increase your dose. Once your condition improves and you are better for a while, then your doctor can work with you to reduce your regular dose. Follow your doctor’s instructions carefully. Do not take more or less medication or take more than prescribed. There will be no improvement in your situation and the risk of side effects will increase.

Use this drug regularly so that it can get the most benefit. To help you remember, use each day at the same time. It may take several weeks for attention to the full benefits of this medication. Do not stop taking this medicine without consultation with your doctor.

This drug may be the reason for the withdrawal reaction, especially if it has been used regularly for long or high doses. In such cases, symptoms of withdrawal (such as discomfort, confusion, hallucinations, headache, weakness and diarrhea) may occur if you suddenly stop using this medicine. To prevent withdrawal responses, your doctor may gradually reduce your dose. Consult your doctor or pharmacist for more information, and immediately report any refund responses.

Inform your doctor if your condition persists or worsens.

Side Effects

See also the warning section.

Problems like dizziness, drowsiness, fatigue, weakness, sleep deprivation, constipation and mouth drying may occur. If any of these effects persists or worsens immediately, inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and lighthouse, slowly rise while sitting or lying down from the position of lying.

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if any of these have potential but serious side effects: Fainting, changes in mental / mood (e.g, movement, confusion), muscle rigidity, change / interest in sexual ability, shaking (tremors), tremors, Inflammatory ankle / leg, abnormal weight gain, eye pain / swelling / redness, changes in vision (e.g, double / blurred vision).

Tell your doctor immediately if none of these is highly unlikely, but there are very serious side effects: severe stomach / stomach ache, persistent nausea / vomiting, seizures, dark urine, yellowing of eyes / skin.

If you have high blood pressure (severe headache), then frequent / severe headache, fast / slow / irregular / fast heartbeat, chest pain, neck stiffness or soreness, severe nausea / any of these symptoms Stop taking  Parnate  or Tranylcypromine immediately and seek medical help. Vomiting, sweating / stinky skin (sometimes with fever), wide braces, sudden sensitivity to light (photophobia).

This drug can increase serotonin and rarely cause a very serious condition, which is called serotonin syndrome / toxicity. The risk increases if you are taking other medicines that increase the serotonin, so tell your doctor or pharmacist about all the medicines that you take (see the drug interaction section). Get medical help immediately when some of the following symptoms develop: Fast heartbeats, hallucinations, loss of coordination, severe dizziness, severe nausea / vomiting / diarrhea, muscle shaking, unexplained fever, abnormal movement or restlessness

There is no possibility of a serious allergic reaction to this drug, but if this happens, seek immediate medical attention. Symptoms of a severe allergic reaction include: rashes, itching / swelling (especially the face / tongue / throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking Parnate or Tranylcypromine, tell your doctor or pharmacist whether you are allergic to it; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using this drug, tell your doctor or pharmacist your medical history, in particular: a certain type of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), high blood pressure, heart problems (e.g., Coronary artery disease, chest pain, heart attack, heart failure), severe / persistent headache, mental / mood disorders (e.g., schizophrenia, bipolar disorder) ), Problems with liver, kidney disease, a disease of the nervous system (Parkinson’s syndrome, seizures), overactive thyroid  (hyperthyroidism), personal / family history of glaucoma (angle-closure type).

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution. Avoid alcoholic beverages. If you are using marijuana, talk to your doctor.

Before requiring the use of contrast dye (e.g., myelography) in surgery or in any process, tell your doctor or dentist that you are on this drug. You may have to stop taking this medicine in advance. Follow your doctor’s instructions carefully.

If you have heart disease, then this medicine can cause chest pain. Avoid strenuous exercise while taking this medicine.

If you have diabetes, then Parnate can reduce your blood glucose. Regularly check your blood glucose and share the results with your doctor. Tell your doctor immediately if you have symptoms of low blood sugar such as sudden sweating, shock, fast heartbeat, hunger, blurred vision, dizziness or twisting of hands / feet. Your doctor may need to adjust your diabetes medication, exercise program or diet.

It is advisable to use caution in the elderly, because they may be more susceptible to the effects of medication, especially the effect on blood pressure.

Parnate should be used only when explicitly required during pregnancy. Discuss the risks and benefits with your doctor.

Since untreated mental / mood disorders (such as depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning a pregnancy, become pregnant, or think that you may be pregnant, discuss the benefits and risks of using your medicine immediately during your pregnancy.

This medication passes into breast milk. Consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that may interact with Parnate or Tranylcypromine include:  antidepressants  (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (isocarboxazidlinezolid, methylene blue, moclobemide,   phenelzine,   procarbazinerasagiline, safinamide,  tranylcypromine), appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine,   methylphenidate),  apraclonidine,  buspirone, carbamazepine/oxcarbazepine, cyclobenzaprine, deutetrabenazine, certain herbal products (such as ephedra/ma huang), cold medications/nasal decongestants (such as phenylephrine,  phenylpropanolamine, pseudoephedrine), fentanyl, street drugs (such as LSD, mescaline), stimulants (such as amphetamines,  ephedrine),  supplements (such as tryptophan, tyramine), tetrabenazine, certain “triptans” used to treat migraine headaches (such as rizatriptan,  sumatriptan, zolmitriptan), valbenazine.

If you are taking other medicines that increase serotonin then the risk of serotonin syndrome / toxicity increases. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, dextromethorphan, certain  antidepressants (including SSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxine, TCAs such as amitriptyline/doxepin), certain narcotic medications (such as meperidine, methadone, pentazocine, propoxyphene, tramadol, tapentadol), among others. The risk of serotonin syndrome / toxicity can be higher when you start or increase the dose of these medicines.

Tell your doctor or pharmacist whether you are using any of these medicines before or after the treatment with Parnate within 2 weeks. Tell your doctor or pharmacist whether you have taken fluoxetine at least 5 weeks before starting Parnate. Discuss with your doctor how much time to wait in between starting or preventing any of these medicines and taking Parnate.

Tell your doctor or pharmacist whether you are taking other products, due to opiate pain or cough relief (such as codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as alprazolam, lorazepam, zolpidem) , Muscles are relaxing (Such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizinediphenhydramine).

Check the label on all your drugs (such as allergens, cough-and-cold products, diet pills) because they may contain dextromethorphan,  decongestants,  stimulant, or material that causes drowsiness. Ask about the safe use of those products from your pharmacist.

It is very important that you follow special dietary restrictions to limit the amount of tyramine in your diet. Avoid drinking large quantities of beverages containing caffeine (coffee, tea, cola) or eating large amounts of chocolate. Caffeine can increase the side effects of this drug. When you stop using this medicine, you should avoid high food and beverages in the tyramine while taking this medicine for at least 2 weeks.

High food items include: aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef/chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts, fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread, kim chee (Korean fermented cabbage), orange pulp, overripe or spoiled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soybeans, soybean paste/miso, tofu, tap beer and ale, vermouth.

Moderate-to-low tyramine content foods include: Alcohol-free beer, avocados, bananas, bottled beer and alley, chocolate and chocolate, coffee, cola, with cultured dairy products (such as buttermilk, curd, sour cream) Distilled products, distilled Spirits, eggplant, canned figs, fish roe (caviar), green bean pods, peat, peanuts, port wine, raisins, raspberry, red plums, spinach, tomatoes, white wine.

Tell your doctor or pharmacist immediately if you have symptoms such as high blood pressure symptoms such as fast / slow heartbeats, vomiting, sweating, headache, chest pain, changes in sudden sight, weakness on one side of the body.

Contact your healthcare professionals (e.g., doctor, pharmacist, dietician) for more information, including recommendations for your diet.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center.


Do not share this medication with others.

Laboratory and / or medical tests (e.g, blood pressure, liver function) should be periodically monitoring your progress or checking side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, remember as soon as possible until the next scheduled dose is within 2 hours. In that case, leave the missed dose and determine your normal dose. Do not double the dose to catch up.


Store at room temperature between 59-86 ° F (15-30 ° C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your drug dealer or local waste disposal company to get more information about safely terminating your product.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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