Omeprazole: Side Effects, Dosage, Uses, and More



Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcer). It works by reducing the amount of acid produced in your stomach. It relieves heartburn, difficulty in swallowing and persistent cough symptoms. Omeprazole helps in stomach and esophagus to cure acid damage, helps in preventing ulcers, and can help to prevent esophageal cancer. Omeprazole comes under a class of protons pump inhibitors (PPI).

If you are self-medicating with this medicine, over-the-counter omeprazole products are often used for heartburn (2 or more days a week). Since full effect can take 1 to 4 days, so these products do not immediately relieve heartburn.

For over-the-counter products, be sure to read the package instructions carefully to ensure that the product is right for you. Check the materials on the label even if you have used the product before. The creator may have changed the ingredients. Apart from this, products with similar brand names may have different content for different purposes. Taking the wrong product can harm you.

How to use Omeprazole

If you start taking omeprazole and you get a refill, then before you are available from your pharmacist, please read the Patient Information Letter.

Take Omeprazole from the mouth, as directed by your doctor, usually once before meals. If you are self-healing then follow all the instructions on the product package. Dosage and length of treatment is based on the reaction of your medical condition and treatment. In children, dosage is also based on weight. Do not increase your dose or take this medicine more often than directed. If you have any questions, ask your doctor or pharmacist.

Do not let the bullets crush, break or chew. Swallow this medicine completely with a glass of water.

If necessary, antacids can be taken with this medicine. If you are also taking sucralfate, take omeprazole at least 30 minutes before sucralfate.

Use Omeprazole regularly to get the most benefit. To help you remember, take it every day at the same time. Continue taking this medicine for a fixed length of treatment, even if you are feeling better. If you are self-treating with over-the-counter products, do not take it for more than 14 days unless directed by your doctor.

Tell your doctor if your condition persists or worsens. If you are self-healing, tell your doctor whether your heartburn persists after 14 days or if you have to use this medicine more than once every 4 months. Over time, the risk of side effects increases. Ask your doctor how long you should take this medicine. If you feel that you may have a serious medical problem, immediately seek medical help.

Side Effects

See also the Precautions section.

There can be pain in the headache or stomach. If any of these effects persists or worsens, tell your doctor or pharmacist immediately.

If your doctor has directed you to use this product, remember that he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if you have any serious side effects, including the following: Lower magnesium blood level symptoms (such as abnormally fast / slow / irregular heartbeats, frequent muscle spasms, visits), Lupus signs (e.g Rash on the nose, pain of new or worsening joints).

Due to the type of bacteria, Omeprazole can rarely cause the intestinal severity (Clostridium difficile-associated diarrhea). If you have any of the following symptoms, do not use anti-diarrhea or opioid drugs because these products can make them worse. Tell your doctor immediately if you develop: Constant diarrhea, stomach or stomach aches / cramps, fever, blood / sputum in your stools

Rarely, proton pump inhibitors (such as omeprazole) lack vitamin B12. The risk is increased if they are taken for long periods of time (for 3 years or more). Tell your doctor immediately if you develop symptoms of vitamin B12 deficiency (such as abnormal weakness, tongue in the throat, or numbness / tingling of hands / feet)

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get immediate medical help, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, shortness of breath, Symptoms of renal problems (such as changes in urine volume)

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking omeprazole, tell your doctor or pharmacist whether you are allergic to it; Or for similar drugs (such as esomeprazole, lansoprazole, pantoprazole); Or if you have any other allergens. This product may contain passive elements, which may cause allergic or other problems. Talk to your pharmacist for more details.

Before using Omeprazole, tell your doctor or pharmacist your medical history, in particular: liver disease, Lupus.

Some symptoms may actually be signs of a more serious condition. If you get immediate medical help: jealousy / sweating / dizziness with heartburn, chest / jaw / hand / shoulder pain (especially shortness of breath, abnormal sweating), unexplained weight loss

Also, before you self-treat it with Omeprazole, get immediate medical help if you have any of these signs of serious condition: food for trouble / pain, bloody vomiting, vomiting coffee grounds, Looks like bloody / black stools, upset for more than 3 months, frequent chest pain, frequent wheezing (especially with heartburn), nausea / vomiting, abdominal pain.

Proton pump inhibitors (such as omeprazole) can increase your risk for bone fractures, especially in long-term use, high dose and in older adults. Talk to your doctor or pharmacist about ways to prevent bone loss / fracture, such as calcium (such as calcium citrate) and vitamin D supplements.

Children may be more susceptible to the side effects of Omeprazole, especially due to fever, cough and nasal / throat / airway infections.

Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).

During pregnancy, Omeprazole should be used only when explicitly necessary. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. The effect on a nursing infant is unknown. Consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some of the products that interact with Omeprazole include:  cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John’s wort.

Some products require acids in the stomach so that the body can absorb them properly. Omeprazole reduces stomach acids, so it can change how well these products work. Some affected products include atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole).

Omeprazole is similar to esomeprazole. Do not use any medication containing esomeprazole when using omeprazole.

Omeprazole can interfere with some laboratory tests, possibly causing false test results. Ensure that the lab staff and all your doctors know that you use this medicine.

Over Dose

If someone is treated and has serious symptoms such as difficulty in getting out or breathing, call 911. Otherwise, call the Poison Control Center immediately. American residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: confusion, abnormal perspiration, blurred vision, abnormally fast heartbeat.


If your doctor has prescribed this medicine for you, do not share it with others.

If your doctor gives you instructions on how to use this medication for a long period of time, then laboratory and medical tests (such as a magnesium blood test, vitamin B-12 levels) monitor your progress or check the side effects Can be done from time to time. Keep all regular medical and laboratory appointments.

Missed Dose

If you miss a dose, then as soon as you remember it, take it. If it is near the next dose time, then leave the thesis dose and set your normal dose. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed to do so, do not flush the medicines under the toilet or drain them in the drain. When this period expires or does not require it, then properly release this product. Consult your pharmacist or local waste disposal company.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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