Monomethyl Fumarate – Uses-side effects-doses-interactions and Reviews

Why is this drug recommended?

Adults with different kinds of multiple sclerosis (MS; a condition in which the nerves malfunction and patients may have weakness, numbness, loss of muscular coordination, issues with vision, speech, and bladder control) may be treated with monomethyl fumarate, including:

Clinically isolated syndrome (CIS; periods of nerve symptoms lasting at least 24 hours), relapsing-remitting forms (disease progression in which symptoms sometimes flare up), or secondary progressive forms (disease progression in which relapses happen more frequently).
The drug monomethyl fumarate belongs to the family of drugs known as Nrf2 activators. It functions by reducing inflammation and averting nerve damage that might result in multiple sclerosis symptoms.

Monomethyl Fumarate – Uses-side effects-doses-interactions and Reviews

How is this medication to be Used?

Monomethyl fumarate is available as a delayed-release capsule that has to be swallowed. This prevents stomach acids from breaking down the medicine. Typically, it is taken twice day. Take monomethyl fumarate every day at around the same time. Ask your doctor or chemist to clarify any instructions on your prescription label that you are unsure about following. Follow the monomethyl fumarate directions exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

You can take monomethyl fumarate with or without meals.

Do not chew or crush the capsules; instead, swallow them whole. Never crack the capsules open or sprinkling the powder over meals.

To lessen the possibility of flushing (facial redness) during your treatment, you may take a non-enteric coated aspirin (325 mg or less) 30 minutes beforehand.

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Most likely, your doctor will put you on a low dose of monomethyl fumarate and gradually raise it over the course of 7 days.

Monomethyl fumarate won’t cure multiple sclerosis, but it could help manage it. If you feel OK, keep taking monomethyl fumarate. Without consulting your doctor, do not discontinue taking monomethyl fumarate.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other use for this drug

Ask your doctor or chemist for further details if you believe this drug should be used for something else.

What specific safety measures should I take?

Inform your doctor and chemist if you have any allergies prior to using monomethyl fumarate, including those to dimethyl fumarate (Tecfidera), diroximel fumarate (Vumerity), other drugs, or any of the substances in monomethyl fumarate capsules. For a list of the chemicals, see your chemist or the manufacturer’s patient information.
Inform your doctor if you are taking either diroximel fumarate (Vumerity) or dimethyl fumarate (Tecfidera). If you are taking one of these drugs, your doctor will probably advise you not to take monomethyl fumarate.

If you have or have ever had chickenpox, herpes zoster (shingles; a rash that can happen to people who have had chickenpox in the past), a low white blood cell count, liver disease, or kidney disease, let your doctor know. Also mention any type of infection, including transient and persistent infections.
Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking monomethyl fumarate.
What specific dietary recommendations should I abide by?
Keep eating normally unless your doctor instructs you differently.

How should I proceed if I forget to take a dose?

If you miss a dosage, take it as soon as you recall. If the next dosage is soon due, skip the missed one and carry on with your normal dosing plan. To make up for a missing dosage, do not take a second one.

What Side effects may this medicine have?

Side effects from monomethyl fumarate are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:
Skin that is heated, red, itchy, or burning
diarrhea
nausea
vomiting
heartburn
stomach pain
hair loss
runny nose
Some adverse effects can be quite harmful. Stop taking monomethyl fumarate and seek immediate medical attention if you suffer any of the following symptoms:
breathing or swallowing challenges
Hives, rash, itching, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
hoarseness
a persistent weakness on one side of your body, awkwardness in your arms or legs, eyesight issues, modifications to your thinking or memory, disorientation, or changes in your personality.
Extreme fatigue, appetite loss, upper right stomach ache, dark urine, yellowing of the skin or eyes, coughing, sore throat, fever, warm, red, or painful skin, or other infection-related symptoms
persistent stomach discomfort that sometimes radiates to the back, along with nausea, vomiting, and appetite loss
Other negative effects of monomethyl fumarate are possible. If you have any strange side effects while taking this medicine, contact your doctor right once.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you suffer a significant adverse event.

What should I be aware of about the handling and disposal of this medication?
Keep this medication securely closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and away from light, excessive heat and moisture.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from small children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent dogs, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a drug take-back programme is the ideal approach to get rid of your medicines. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

In the event of a crisis or overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, has a seizure, is having difficulty breathing, or cannot be roused.

What additional details should I be aware of?

Keep all of your appointments with your physician and the lab. Prior to starting your therapy and throughout it, your doctor might request a blood test to monitor how your body is responding to monomethyl fumarate.

No one else should take your medicine. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergency.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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