Metoclopramide Oral : Uses, Side Effects & Interactions



Metoclopramide is used to treat certain conditions of stomach and intestines. Metoclopramide is used as a short-term treatment (4 to 12 weeks) for persistent heartburn when normal medicines do not work well. It is used mostly for heartburn, which occurs after the meal or during the day. Chronic heartburn treatment can reduce the damage to the swelling of the stomach acid (esophagus) and help in the treatment.

Metoclopramide is also used in diabetic patients, whose poor (gastroparesis) poorer are empty. Treatment of gastroparesis can reduce the symptoms of nausea, vomiting, and stomach fullness. Metoclopramide works by blocking a natural substance (dopamine). It accelerates the stomach and speed up the intestines.

Due to the increased risk of severe side-effects (such as muscle cramps / uncontrolled motion movements), it is not recommended to use this drug in children. Ask the doctor or pharmacist for information.

How to use Metoclopramide Hcl

See also the warning section.

Before starting to take a Metoclopramide, read the medicine guide given by your pharmacist and every time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take Metoclopramide 30 minutes before meals and at bedtime, usually 4 times a day, or exactly as prescribed by your doctor. If you are using the liquid form of this drug, then carefully measure the dose using special measurement equipment / spoon. Do not use domestic spoon because you can not get the right dose.

If you are using a disruptive tablet, do not remove the tablet from the blister pack just before your dose. Before using this medicine, dry your hands. Do not use the tablet if it is broken or rigid. Immediately after taking the tablet, put it on the tongue. Allow it to completely dissolve, then swallow it with saliva. You do not have to take this product with water.

Dosage is based on your medical condition, treatment response, age and other medicines you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including Prescription Drugs, nonprescription Drugs and Herbal Products).

If jealousy occurs only at certain times (like after the evening meal), then your doctor may instruct you before taking dose once instead of taking the day. This will reduce the risk of side effects.

Due to the risk of tardive dyskinesia, do not take it longer than it is, in a large dose, or directed by your doctor. According to the manufacturer, the treatment should not be more than 12 weeks.

To treat diabetes gastroparesis, this medicine is usually taken for 2 to 8 weeks until your gut is not working well. This situation can be repetitive from time to time. Your doctor can direct you that as soon as your symptoms appear again and when you feel better, start taking this medicine. Take instructions from your doctor to start and stop this medicine.

Take Metoclopramide regularly as it provides the most benefit. To help you remember, take it at the same time each day before meals.

If Metoclopramide is used regularly in a long or high amount, then symptoms of withdrawal (such as dizziness, anxiety, headache) can occur if you suddenly stop using this medicine. To prevent withdrawal responses, your doctor may gradually reduce your dose. Consult your doctor or pharmacist for more information, and immediately report any refund responses.

Tell your doctor if your condition persists or worsens.

Side Effects

See also the warning section.

Sleepiness, dizziness, fatigue, difficulty in sleep, movement, headache and diarrhea may occur. If any of these effects persists or worsens, tell your doctor or pharmacist immediately.

Remember that your doctor has prescribed this drug because he or she has decided that your benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if you have any serious side effects, including: changes in mental / mood (such as anxiety, delusion, depression, thoughts of suicide), lack of sexual ability, still inability to keep / need speed, muscles The symptoms of cramping / uncontrolled muscles (such as neck stiffness, back stiffness), Parkinson’s symptoms (such as movement, slow / hard movement, mask-like faces Mr. expression), abnormal breast milk production, enlarged / tender breasts, arm or leg swelling, changes in menstrual periods in women.

Metoclopramide can rarely cause a very serious condition, which is called neuroleptic malignant syndrome (NMS). If you have any of the following symptoms, seek medical help: fever, muscle stiffness, severe confusion, sweating, sharp / irritability.

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, shortness of breath

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In the US –

Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking metoclopramide, tell your doctor or pharmacist whether you are allergic to it; Or if you have any other allergens. This product may contain passive elements, which may cause allergic or other problems. Talk to your pharmacist for more details.

Before taking this medicine, tell your doctor or pharmacist your medical history, in particular: the history of movement / muscular disorder (like tardive dyskinesia, dystonia) is due to a drug, bleeding in the intestinal / stomach, breast cancer / Obstruction / holes high blood pressure, kidney problems, cardiovascular failure, mental / mood disorders (such as depression, thoughts of suicide), Parkinson’s disease, liver problems (such as cirrhosis, porphyria), pheochromocytoma, seizures, a certain blood enzyme problem (lack of NADH-cytochrome b5 reductase).

Metoclopramide may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do this, do not drive, use machinery, or do anything that requires caution. Limit alcoholic beverages If you are using marijuana, talk to your doctor.

Liquid products can contain alcohol. If you have diabetes, dependence on alcohol, liver disease, or any other condition in which you need to limit alcohol, it is advisable to take precautions. Ask your doctor or pharmacist about using this product safely.

Disruption tablets may have aspartame or phenylalanine. If you have phenylketonuria (PKU) or any other condition that you need to limit / avoid aspartame or phenylalanine in your diet, ask your doctor or pharmacist about making safe use of this drug.

Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).

If you have diabetes, Metoclopramide can make it difficult to control your blood glucose. Regularly check your blood glucose as directed and share the results with your doctor. Tell your doctor immediately if you have high or low blood sugar. Your doctor may need to adjust your diabetes medicine, exercise program or diet.

Children may be more susceptible to the side effects of this drug, especially muscle spasms / uncontrolled muscle movements. See also the usage section.

Older adults may be more susceptible to the effects of this drug, especially the problems of drowsiness, jerky dysnesia and Parkinson type muscles. Sinking can increase the risk of falling.

During pregnancy, Metoclopramide should be used only when explicitly necessary. Discuss the risks and benefits with your doctor.

This medicine passes in breast milk and may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some of the products that interact with this drug include: antipsychotic (such as aripiprazole, haloperidol), atovaquone, dopamine agonist (such as cabergoline, pergolide, ropinirole), fosfomycin, pramlintide, phenothiazines (e.g promethazine, prochlorperazine), rivastigmine.) .

Metoclopramide causes the food and drug to move faster through your stomach, which can affect the absorption of certain drugs. Talk to your doctor or pharmacist whether the medicine you are taking may be affected.

Tell your doctor or pharmacist whether you are taking other products including alcohol, marijuana, antihistamine (such as cetirizine, diphenhydramine), sleep or anxiety medicines (such as  alprazolam, diazepam, zolpidem), muscle relaxants, and alcoholic pain . Relievers (such as codeine).

Check the label on all your drugs (like allergy or cough-and-cold products), because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Over Dose

If someone is treated and has serious symptoms such as difficulty in getting out or breathing, call 911. Otherwise, call the Poison Control Center immediately. American residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center.


Do not share this medicine with others.

Laboratory and / or medical tests (such as Endoscopy for Ulcers) can be performed from time to time to monitor your progress or check side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, then as soon as you remember it, take it. If it is near the next dose time, then leave the thesis dose. Take your next dose at regular times. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Until instructed to do so, do not flush the medicines under the toilet or drain them in the drain. When this period expires or does not require it, then properly release this product. Consult your pharmacist or local waste disposal company.

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