Janumet Oral : Uses, Side Effects, Interactions


GENERIC NAME(S): Sitagliptin-Metformin


This combination drug is used with proper diet and exercise programs and possibly other medicines to control high blood sugar. It is used in type 2 diabetic patients.

There are 2 drugs in this product. Sitagliptin works by increasing the increasing levels of natural substances called incretins. incretins help to control blood sugar by increasing the release of insulin, especially after meals. They also reduce the amount of sugar that makes up your liver. Metformin works by helping your body regain proper responses to naturally produced insulin. It reduces the amount of sugar that makes up your liver and absorbs your stomach / intestines.

Controlling high blood sugar helps prevent kidney damage, blindness, nervous problems, loss of organs and sexual function problems. Proper control of diabetes may reduce the risk of heart attack or stroke.

How to use Janumet

Before starting using sitagliptin/metformin, read the medication guide provided by your pharmacist and every time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medicine guided by your doctor, usually with food two times a day. While taking this medicine drink plenty of fluids until it is directed by your doctor. The manufacturer directs not to divide / break / cut the tablet before taking it. However, many similar drugs (instant-release tablet) can be split / cut. Follow your doctor’s instructions on how to take this medication.

Dosage is based on your medical condition, reaction to treatment and other medicines you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including Prescription Drugs, nonprescription Drugs and Herbal Products). To reduce your risk of side effects (such as stomach upset), your doctor may direct you to start this medication on low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take Janumet regularly so that it can get the most benefit. Remember to use it at the same time each day.

If you are already taking another diabetes medication (such as pioglitazone), then follow your doctor’s instructions carefully to stop / continue the old medicine and start this drug. Carefully follow the medication treatment plan, diet plan and exercise program recommended by your doctor.

Regularly check blood sugar guided by your doctor. Take care of the results, and share them with your doctor. Tell your doctor if your blood glucose measurement is too high or too low. Your diet / treatment may need to be changed.

Side Effects

See also the warning section.

Nausea, vomiting, stomach upset, diarrhea, headache, weakness, or a metal taste may occur in the mouth. If any of these effects persists or worsens, tell your doctor or pharmacist immediately. If symptoms of stomach return later (after taking a single dose for several days or weeks), tell your doctor immediately. The signs of stomach arising after the first days of your treatment can be signs of lactic acidosis.

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using Janumet do not have serious side effects.

Janumet is usually not the cause of low blood sugar (hypoglycemia). If this medicine is prescribed with other diabetes drugs then low blood sugar can occur. Talk to your doctor or pharmacist if you have low doses of other diabetes medicines.

Symptoms of Low Blood Sugar include sudden sweating, tremors, pulsation, hunger, blurred vision, dizziness or jerking of hands / feet. It is a good habit to take glucose tablets or gels to treat low blood sugar. If you do not have these reliable forms of glucose, increase your blood glucose faster by drinking instant sugar such as table sugar, honey, or candy, or fruit juice or non-diet soda. Tell your doctor about immediate reaction. The probability of low blood sugar is high if you drink large amounts of alcohol, do unusually heavy exercises, or do not consume enough calories from food. To help prevent low blood glucose, dine on a regular basis, and do not leave food. To find out from your doctor or pharmacist to find out what you need to eat.

Symptoms of high blood sugar (hyperglycemia) include thirst, increase in urine, confusion, drowsiness, flushing, rapid breathing, and breath odor. If these symptoms occur, tell your doctor immediately. Your doctor may need to adjust your diabetes medication.

Tell your doctor away from any serious side effects, including: signs of kidney problems (such as changes in urine volume), joint pain, abnormal skin blisters, symptoms of heart failure (such as shortness of breath, swelling Ankle / foot), abnormal fatigue, abnormal / sudden weight gain).

If you have a very serious side effect, seek medical help, including: symptoms of pancreatitis (such as frequent nausea / vomiting, loss of appetite, severe stomach / stomach / back pain), lactic acidosis (see warning section) .

A very serious allergic reaction to this drug is rare. However, if you see any of the following symptoms of a serious allergic reaction, seek medical help immediately: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, breathing difficulties

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


See also the warning section.

Before taking Janumet, tell your doctor or pharmacist whether you are allergic to sitagliptin or metformin; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using Janumet, tell your doctor or pharmacist your medical history, especially: severe breathing problems (such as lung disease, severe asthma), blood problems (such as anemia, vitamin B-12 deficiency ), Kidney disease, liver disease, disease pancreas (pancreatitis), stones in your gallbladder (gallstones)

Before doing surgery or using an x-ray / scanning process using iodine-containing contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs and herbal products) . You may have to stop this medication for a short time for surgery. Ask your doctor or dentist for instructions before your surgery / procedure.

You may experience blurred vision, dizziness or drowsiness due to very little or high blood sugar. Do not drive, use machinery, or do any such activity for which you need a vigilance or a clear vision unless you are sure you can do such activities safely.

Limit alcohol while using Janumet because it can increase your risk of developing lactic acidosis and low blood sugar.

Due to high fever, “water pills” (diuretics such as hydrochlorothiazide), excessive sweating, diarrhea, or vomiting can cause excessive body water (dehydration) and can increase the risk of lactic acidosis. Stop taking this medicine and tell your doctor immediately if you have diarrhea or vomiting for a long time. Be sure to drink enough liquids to prevent dehydration until your doctor prescribes you otherwise.

When your body is stressed (such as a fever, infection, injury, or surgery), it can be difficult to control your blood glucose. Consult your doctor because the increased stress may require a change in your treatment plan, medicines, or blood sugar test.

Older adults may be at greater risk for side effects like low blood sugar or lactic acidosis.

During pregnancy, Janumet should be used only when it is clearly necessary. Discuss the risks and benefits with your doctor. Your doctor may direct you to use insulin instead of this product during your pregnancy. Follow your doctor’s instructions carefully.

Metformin can cause a change in the menstrual cycle (boosting ovulation) and can increase the risk of getting pregnant. Consult your doctor or pharmacist about using reliable birth control while using this medication.

Metformin passes in a small amount of breast milk. It is unknown if cystagliptin passes in breast milk. Consult your doctor before breastfeeding.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Overdose can lead to lactic acidosis. Symptoms of overdose may include: severe drowsiness, severe nausea / vomiting / diarrhea, rapid breathing, slow / irregular heartbeat.


Do not share this medication with others.

Participate in the Diabetes Education Program to learn more about how to manage your diabetes with medicines, diet, exercise and regular medical examinations.

Learn the symptoms of high and low blood sugars and how to treat low blood glucose. Check your blood sugar regularly as directed.

Labs and / or medical tests (such as Kidney Function, Liver Function, Blood Sugar, Hemoglobin A1c, Complete Blood Counts) should be done before taking this medicine and when you are taking it. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose

If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis dose. Take your next dose at regular times. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your drug dealer or local waste disposal company to get more information about safely terminating your product.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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