Eldepryl Oral : Uses, Side Effects, Interactions


GENERIC NAME(S): Selegiline Hcl


Selegiline, sold under the trade name Eldepryl among others. This drug is used to treat the disorders caused by Parkinson’s disease. It does not cure Parkinson’s disease, but it can damage the shakiness, muscle stiffness, normal movement, because your other Parkinson’s drug supplements stop (end-of-dose failure), and suddenly a normal movement And switch between hardness (“on-off” problems). It can improve your speed and ability to walk, wear and exercise. Eldepryl is usually used with other drugs (e.g., levodopa, carbidopa).

Eldepryl is an enzyme inhibitor (MAO inhibitor) that works by slowing down the breakdown of natural substances in the brain (such as dopamine, norepinephrine, and serotonin).

How To Use Eldepryl

Take this medicine from mouth, usually with breakfast and lunch, daily. Taking late Eldepryl or Selegiline can cause sleep problems. Dosage is based on your medical condition and medical reaction. Do not increase your dose or take more than directed.

When you are taking Eldepryl for 2 or 3 days, your doctor may direct you to reduce levodopa supplements. Follow your doctor’s instructions closely. Do not stop or refuse the dose of any of your medicines without first talking to your doctor.

It may take a few weeks to focus on the full benefits of the medication. Do not stop taking this medicine without consulting your doctor first. Talk to your doctor if the medicine stops working well or if your condition worsens.

Side Effects

Dizziness, stomachache, dry mouth, nausea, stomach upset, sleepiness, and headache can occur. If any of these effects persists or worsens immediately, inform your doctor or pharmacist immediately.

If you are taking Levodopa too, you may experience more side effects than levodopa for taking Eldepryl or Selegiline. Tell your doctor immediately if any of these side effects occur: Nausea, shock, muscle stiffness, change in mental / mood such as hallucinations / unusual dreams Your doctor may need to change your medication or dosage. Do not stop or change your levodopa dose without first talking to your doctor.

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Some people who take Eldepryl have suddenly slept during their normal daily activities (such as talking on the phone, driving). In some cases, sleep has already happened without feelings of sleepiness. This sleeping effect can occur at any time with treatment with Eldepryl, even if you have used this drug for a long time. If you experience an increase in sleep during the day or fall asleep, do not drive or participate in other potentially dangerous activities, unless you have discussed this effect with your doctor. Your risk of the effect of this sleep increases with the use of alcohol or other medicines that can make you dull. See also the Precautions section.

Tell your doctor immediately if you have a serious side effect, including: unconsciousness, loss of balance, changes in mental / mood (e.g, movement, delusion, depression, hallucinations), unusual strong urges (such as increase in gambling, sexual stimulation Increase), stiffness of deteriorating muscles / mutilation, sexual ability / changes in interest, increased shiver (shaking), swollen ankle / leg, difficulty in urinating, abnormal weight gain Education, easy bleeding / injury, black / Terry sewage, vomit that looks like ground coffee.

This drug can rarely cause the attack of hypertension (high blood pressure), which can be fatal. Many drug and food interactions can increase this risk. (See also drug interaction section.) Get medical help immediately if any of these serious side effects: frequent / severe headache, fast / slow / irregular / fast heartbeat, chest pain, neck stiffness / soreness, serious Nausea / vomiting, sweating / clammy skin (sometimes with fever), wide pupil, change in vision (e.g, double / blurred vision), sudden sensitivity towards light (photophobia).

This medicine can increase serotonin and rarely produces a very serious condition called serotonin syndrome. The risk increases if you are taking other medicines which increase the serotonin, so tell your doctor or pharmacist about all the medicines that you take. Get medical help immediately when some of the following symptoms develop: hallucinations, abnormal discomfort, loss of coordination, rapid heart beat, severe dizziness, unclear fever, severe nausea / vomiting / diarrhea, twitch muscle.

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help, including: granular, itching / swelling (especially the face / tongue / throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking Eldepryl or Selegiline, tell your doctor or pharmacist whether you are allergic to it; Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using this drug, tell your doctor or pharmacist your medical history, in particular: a certain type of adrenal gland tumor (pheochromocytoma), cerebrovascular disease (e.g., stroke), heart problems (e.g., congestive cancer Failure, heart attack), bleeding problems, severe / frequent headache history, peptic ulcer, diabetes, mental / mood disorders, personal / Family history (e.g., schizophrenia, bipolar disorder), high blood pressure, liver disease, personal / family history of hyperthyroidism.

Eldepryl may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution. Limit alcoholic beverages. If you are using marijuana, talk to your doctor. See also the Side Effects section.

To reduce the risk of dizziness and unconsciousness, slowly rise while sitting or lying down from the position of lying.

Before surgery, tell your doctor or dentist that you are taking this medicine. You may have to stop taking this medicine in advance. Follow your doctor’s instructions carefully.

Eldepryl should be used only when it is clearly necessary during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether or not this drug passes in breast milk. Consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that may interact with Eldepryl or Selegiline include:  antidepressants  (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (isocarboxazidlinezolid, methylene blue, moclobemide,   phenelzine,   procarbazinerasagiline, safinamide,  tranylcypromine), appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine,   methylphenidate),  apraclonidine,  buspirone, carbamazepine/oxcarbazepine, cyclobenzaprine, deutetrabenazine, certain herbal products (such as ephedra/ma huang), cold medications/nasal decongestants (such as phenylephrine,  phenylpropanolamine, pseudoephedrine), fentanyl, street drugs (such as LSD, mescaline), stimulants (such as amphetamines,  ephedrine),  supplements (such as tryptophan, tyramine), tetrabenazine, certain “triptans” used to treat migraine headaches (such as rizatriptan,  sumatriptan, zolmitriptan), valbenazine.

If you are taking other medicines that increase serotonin then the risk of serotonin syndrome / toxicity increases. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, dextromethorphan, certain  antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine, TCAs such as amitriptyline/doxepin), certain narcotic medications (such as meperidine, methadone, pentazocine, propoxyphene, tramadol, tapentadol), among others. The risk of serotonin syndrome / toxicity can be higher when you start or increase the dose of these medicines.

Tell your doctor or pharmacist whether you are using any of these medicines, during treatment with Eldepryl, within 2 weeks. Tell your doctor or pharmacist whether you have taken fluoxetine at least 5 weeks before starting Eldepryl. Discuss with your doctor how much time to wait for between starting or preventing any of these medicines and Eldepryl.

Check the label on all your drugs (e.g allergy, cough-and-cold products, diet pills) because they may include dextromethorphan, decongestant or stimulants. Ask about the safe use of those products from your pharmacist.

To stop the reaction of very serious hypertension, it is very important that you follow a special diet recommended by your doctor or dietician so that you can limit your intake of thymine while taking this medicine. Avoid such food items and drinks, which contain more of the tyramine , which includes: old things (e.g., bleu, cheddar, parmesan), dried / aged / fermented meats and sausages (e.g., salami, liverwurst, preserved fish (e.g., pickled herring), the product contains large amounts of yeast (for example, concentrated yeast extract, bouquet cubes, powder soup / gravy, homemade or sourdough bread), fermented foods (e.g., sauerkraut, kim chee), most soybeans (e.g., soy sauce, tofu), broad/fava beans, red wine, sherry, tap beer, vermouth. Limit such food items or avoid substances that are moderate in the tyramine, These include: avocados, bananas, eggplant, green beans, raisins, raspberries, red plums, spinach, tomatoes, chocolate, cultured dairy products (e.g., buttermilk, curd, sour cream), fish eggs, peat, peanuts, coffee , Cola, alcohol-free beer, bottled beer, distilled spirits, port, a complete list of white wine. Consult your doctor or dietitian for more information and other tyramine-rich foods that you should limit or avoid. If you have symptoms of very high blood pressure, such as abnormally fast / slow heart beat, vomiting, unexplained sweating, headache, chest pain, changes in sudden sight, weakness on one side of the body, sluggish speech Instant medical attention on such symptoms.

This drug can interfere with some medical / laboratory tests (including brain scans for Parkinson’s disease), possibly the result of a wrong test. Ensure that the lab staff and all your doctors know that you use this medicine.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose can not be visible for 12 hours and may include stimuli, irritability, restlessness, dizziness, weakness, drowsiness, flushing, sweating, pulsation, headache, confusion and seizures.


Do not share this medication with others.

People with Parkinson’s disease can increase the risk of developing skin cancer (melanoma). Tell your doctor immediately if you notice changes in appearance or size of moles or other abnormal skin changes. Ask your doctor if your skin should be checked regularly.

Missed Dose

If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis supplement and start your normal dose program again. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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