DTIC : Uses, Side Effects, Interactions & More
DTIC (Dacarbazine) injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer.
DTIC can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you have a low number of blood cells, your doctor may stop or delay your treatment. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising.
DTIC may cause serious or life-threatening liver damage. Liver damage may occur more often in people that are receiving other cancer chemotherapy drugs along with DTIC treatment. If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, or yellowing of the skin or eyes.
DTIC injection has caused birth defects in animals. This medication has not been studied in pregnant women, but it is possible that it may also cause birth defects in babies whose mothers received DTIC injection during pregnancy. You should not use DTIC injection while you are pregnant or plan to become pregnant unless your doctor decides that this is the best treatment for your condition.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body’s response to DTIC.
Talk to your doctor about the risks of using DTIC injection.
Why is this medication prescribed?
DTIC (Dacarbazine) is used to treat melanoma (a type of skin cancer) that has spread to other parts of your body. DTIC is also used in combination with other medications to treat Hodgkin’s lymphoma (Hodgkin’s disease; a type of cancer that begins in a type of white blood cells that normally fights infection). DTIC is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells in your body.
How should this medicine be used?
DTIC injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) over 1 minute or infused intravenously over 15 to 30 minutes by a doctor or nurse in a medical facility. When DTIC is used to treat melanoma, it may be injected once a day for 10 days in a row every 4 weeks or it may be injected once a day for 5 days in a row every 3 weeks. When DTIC is used to treat Hodgkin’s lymphoma is may be injected once a day for 5 days in a row every 4 weeks or it may be injected once every 15 days.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before receiving DTIC,
- tell your doctor and pharmacist if you are allergic to DTIC, any other medications, or any of the ingredients in DTIC injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you are breast-feeding.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. DTIC may make your skin sensitive to sunlight.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What side effects can this medication cause?
DTIC may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- loss of appetite
- sores in the mouth and throat
- hair loss
- feeling of burning or tingling on the face
- flu-like symptoms
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- redness, pain, swelling, or burning at the site where the injection was given
- skin rash
- difficulty breathing or swallowing
- fever, muscle aches, and general feeling of pain and tiredness
DTIC may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.
What other information should I know?
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.