Doxepin Oral : Uses, Side Effects, Interactions

Doxepin HCL Capsule




Doxepin, sold under the brand name Sinequan among others. This drug is used to treat mental / mood problems like depression / anxiety. It can help to improve mood and emotions, remove anxiety and stress, helps you sleep better and increases your energy level. Doxepin is related to a class of drugs called tricyclic antidepressants. It works by affecting the balance of some natural chemicals (neurotransmitters) in the brain.

How To Use Doxepin HCL Capsule

Before starting to take Doxepin, read the medication guide given by your pharmacist and every time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medicine from mouth, usually 1 to 3 times per day or your doctor’s direction. If you take it only once a day, then take it while sleeping to reduce the sleep of the day. Dosage is based on your medical condition and treatment response.

To reduce your risk of side effects (such as drowsiness, dry mouth, dizziness), your doctor may direct you to start this medication on low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take Doxepin regularly so that it can get the most benefit. To help you remember, take it at the same time every day. Do not increase your dose or use this drug more often than prescribed. There will be no improvement in your situation, and the risk of your side effects will increase.

It is important to continue taking this medicine even if you feel OK. Do not stop taking this medicine without consultation with your doctor. When this medicine suddenly stops, some conditions may get worse. In addition, you can experience symptoms like mood swings, headache and fatigue. When you are stopping treatment with this medicine, your doctor may gradually reduce your dose to stop these symptoms. Contact your doctor or pharmacist for more information. Report any new or deteriorating symptoms instantly.

This drug can not work right now. You can have some benefits within a week. However, you can take up to 3 weeks to realize full effect.

Tell your doctor if your situation persists or worsened (like feelings of depression worsen, or you have thoughts of suicide).

Side Effects

See also the warning section.

Drowsiness, dizziness, dry mouth, visible blurred, difficulty constipation or urination. If any of these effects persists or worsens immediately, inform your doctor or pharmacist immediately.

To reduce the risk of dizziness and lighthouse, slowly rise while sitting or lying down from the position of lying.

To relieve dry mouth, suck sugarless hard candies or ice chips, sugarless chewing gum, drink water, or use saliva.

To prevent constipation, maintain adequate diet in the fiber, drink plenty of water and exercise. If you get constipation while using this medicine, then consult your pharmacist to help you choose a laxative.

Remember that your doctor has prescribed Doxepin because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if any of these rare but serious discontent, changes in mental / mood (such as anxiety, movement, confusion), shaking, severe stomach / stomach pain

If you have a very serious side effect, get immediate medical assistance, including: severe dizziness, fast / irregular heartbeat, unconsciousness, seizures, eye pain / swelling / redness, widened pupils, changes in vision (e.g night See the lights in the rainbow).

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, then seek immediate medical attention, including: granules, itching / swelling (especially the face / tongue / throat), severe dizziness, breathing difficulties.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


See also the warning section.

Before taking Doxepin, tell your doctor or pharmacist whether you are allergic to it; Or other tricyclic antidepressants (such as nortriptyline); Or if you have any other allergens. This product can have passive elements, which can cause allergic or other problems. Talk to your pharmacist for more details.

Before using this drug, tell your doctor or pharmacist your medical history, especially: problem of bleeding, trouble breathing, problems of liver, recent heart attack, problems in urinating (such as prostate Due to increase), overactive thyroid (hyperthyroidism), personal or family disease, history of glaucoma (angle-closure type), mental or mood conditions, individual or cross Family history (such as bipolar disorder, psychosis), family history of suicide, visits, situations that can increase the risk of your visit (like other brain diseases, alcohol / sedative withdrawal)

Doxepin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using doxepin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using doxepin safely.

This medication can make you feel dizzy or depressed or blurred your vision. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution or clear vision. Limit alcoholic beverages. If you are using marijuana, talk to your doctor.

Before surgery, tell your doctor or dentist about all the products that you use (including prescription drugs, nonprescription drugs and herbal products).

Doxepin can make you more sensitive to the sun. Keep your time limited in the sun. Avoid Tanning Booths and Sunlamps. Use sunscreen on the outside and wear protective clothing. Tell your doctor immediately if you have sunburned or have blisters / redness on the skin.

If you have diabetes, then this medicine can make it difficult to control your blood glucose level. Regularly monitor your blood glucose levels and tell your doctor about the consequences. Your doctor may need to adjust your diabetes medication, exercise program or diet.

Older adults can be more sensitive to the side effects of this drug, especially dry mouth, dizziness, drowsiness, confusion, difficulty in urinating and QT prolongation (see above).

During pregnancy, this drug should be used only when it is clearly necessary. Since untreated mental / mood problems (such as depression, anxiety) can be a serious condition, do not stop using this medicine unless directed by your doctor. If you are planning a pregnancy, become pregnant, or think that you may be pregnant, discuss the benefits and risks of using your medicine immediately during your pregnancy.

This medicine passes in breast milk and may have undesirable effects on a nursing infant. Breastfeeding is not recommended when using this drug. Consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some of the products that interact with this drug include: arbutamine, thyroid supplements, anticholinergic drugs (such as benztropine, belladonna alkaloids), central-acting drugs to treat high blood pressure (such as clonidine, guanabenz).

Taking the MAO inhibitor with this drug can be a cause of serious (potentially fatal) drug interactions. During treatment with this drug, avoid taking the MAO inhibitor (isocarboxazidlinezolid, methylene blue,  moclobemide,  phenelzine,  procarbazine,  rasagiline,  safinamideselegilinetranylcypromine). Most MAO inhibitors should not be taken for two weeks before and after treatment with this drug. Ask your doctor when to start or stop this medication.

Other medications can affect the removal of doxepin from your body, thereby affecting how doxepin works. These drugs include cimetidine, St. John’s Wort, terbinafine, drugs to treat irregular heart rate (such as quinidine/propafenone/flecainide), antidepressants (such as SSRIs including paroxetine/fluoxetine/fluvoxamine). This is not a complete list.

Many drugs besides doxepin may affect the heart rhythm (QT prolongation in the EKG), including amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using doxepin, report all medications you are currently using to your doctor or pharmacist.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the label on all your drugs (like allergy or cough-and-cold products) because they may include decongestants or elements that cause drowsiness. Ask your pharmacist about using those products safely.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: excessive drowsiness, hallucinations, fast / irregular heartbeat, unconsciousness, slow / shallow breath, seizures.


Do not share this medication with others.

Laboratory and / or medical tests (such as blood count, blood pressure, EKG, liver test) can be done periodically to monitor your progress or to check side effects. Keep all medical appointments. Consult your doctor for more details.

Missed Dose

If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis supplement and start your normal dose program again. Do not double the dose to catch up.


Store at room temperature between 68-77 ° F (20-25 ° C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Until instructed not to do so, do not flush the medicines in the toilet and do not drain in the drain. When this period expires or does not need it, then properly release this product. Consult your drug dealer or local waste disposal company to get more information about safely terminating your product.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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