Chlorpromazine Oral : Uses, Side Effects, Interactions



Chlorpromazine is used to treat certain mental / mood disorders (such as schizophrenia, mental disorder, manic stage of bipolar disorder, serious behavioral problems in children). Chlorpromazine helps you to think more clearly, feel less nervous and participate in everyday life. This can reduce aggressive behavior and the desire to hurt yourself / others. It can help reduce the hallucinations (listening / seeing things that are not there). Chlorpromazine is a psychotherapy drug that belongs to the class of medicines called phenothiazine antipsychotics. It works by helping to restore the balance of some natural substances in the brain.

Chlorpromazine is also used to control nausea / vomiting, prevent prolonged hiccups, remove anxiety / anxiety before surgery, and help in the treatment of tetanus.

How To Use Chlorpromazine HCL

Take Chlorpromazine according to the mouth or with no food, usually 2-4 times daily or as directed by your doctor.

Dosage is based on your medical condition, age, and reaction to treatment. In children, dosage is also based on weight. To reduce your risk of side effects, your doctor may direct you to start this medication on low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit of this. To help you remember, take it every day at the same time.

However, some time after the start of the effect of some medicines, for some conditions, it may take several weeks to get the full benefit of this drug.

Do not stop taking Chlorpromazine without consulting your doctor. When this medicine suddenly stops, some conditions may get worse. In addition, you may experience symptoms like stomach ache, nausea, vomiting, dizziness, and shockness. When you are stopping treatment with this medicine, your doctor can gradually reduce your dose to stop these symptoms. Contact your doctor or pharmacist for more information. Report any new or deteriorating symptoms instantly.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

There may be problems of drowsiness, dizziness, dizziness, dry mouth, blurred vision, fatigue, nausea, constipation, weight gain and sleepiness. If any of these effects persists or worsens, tell your doctor or pharmacist immediately.

Danger and dizziness can increase the risk of falling. Slowly rise while sitting or lying down from the position of lying

Chlorpromazine can cause muscular / nervous system problems (extrapyramidal sumptoms-EPS). Your doctor may prescribe another medication to reduce these side effects. Tell your doctor immediately if you notice any of the following side effects: anxiety / movement / feeling of nervousness, doling / discomfort to swallowing the discomfort, discomfort / persistent walking, shaking (shivering), shaking, hard muscles, Cramped muscle spasm / spasm (such as bent neck, back bending, rolling eyes), facial mask expression

Remember that your doctor has prescribed this drug because he or she has decided that your benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if any of these have potential but serious side effects: difficulty in urination, cough reflex, swelling of the feet, bloating of ankles, butterfly shaped grains on nose and cheeks, joints / muscular pain, skin Disintegration, eye or vision changes, unusually cold or hot.

Generally, Chlorpromazine may cause wrinkles in the face / muscles and uncontrolled movement (tardive dyskinesia). In some cases, this situation can be permanent. Tell your doctor immediately if you develop any uncontrollable movements like sniffing lips, bruising of the mouth, pushing the tongue, chewing or unusual hand / foot movements

In rare cases, Chlorpromazine can increase your level of certain chemicals created by the body (prolactin). For women, this increase in prolactin may have difficulty in getting unsolicited breast milk, missed / paused period or pregnant. For men, it may be due to lack of sexual capacity, inability to produce sperm, or increased breast. If you develop any of these symptoms, then tell your doctor immediately.

Rarely, men may have painful or longer build for 4 or more hours. If this happens, stop using this medicine and seek immediate medical attention, or there may be permanent problems.

Tell your doctor immediately if any of the rare and serious symptoms, signs of infection (such as fever, sore throat in the throat), problems of the liver (such as yellow eyes / skin, dark urine, persistent nausea, vomiting, stomach ache) ), Easy injury / bleeding, symptoms of anemia (such as severe fatigue, acute inhalation, pale skin, pulsation), mental / mood swings (like deteriorating psychosis, unresponsive / catatonic Phase).

If you have any serious side effects, get immediate medical help, including: severe dizziness, unconsciousness, slow breathing / chest pain, seizures

Chlorpromazine can rarely cause a very serious condition, which is called  neuroleptic malignant syndrome (NMS). Get medical help if you have any of the following symptoms: fever, muscle stiffness / pain / tenderness / weakness, severe fatigue, severe confusion, sweating, sharp / irregular heartbeat, deep urine, symptoms of kidney problems (e.g That change) amounts of urination).

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help immediately, including: granular, itching / swelling (especially the face / tongue / throat), severe dizziness, shortness of breath

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


See also the warning section.

Before taking Chlorpromazine, tell your doctor or pharmacist whether you are allergic to it; Or for other phenothiazine medicines (such as  perphenazine, thioridazine); Or if you have any other allergens. This product may contain passive elements, which may cause allergic or other problems. Talk to your pharmacist for more details.

Chlorpromazine should not be used in those people who are intoxicants of alcohol / drugs / other drugs that cause drowsiness or slow / shallow breathing.

Before using Chlorpromazine, tell your doctor or pharmacist your medical history, especially: liver problems, kidney problems, cardiovascular problems (like mitral valve insufficiency, abnormal heart rhythm), low blood pressure, obstruction of intestines , Glaucoma, seizures, drug enlarged prostate, respiratory problems (such as severe asthma, emphysema, lung infection), blood disorders (such as bone marrow Fat, lower red / white / platelet blood cell count), lower levels of calcium in the blood, excess body loss (dehydration), breast cancer, brain disorder / tumor / injury, organophosphate insecticides, pheochromocytoma drug / alcohol / drug Intake of substances, exposure to Parkinson’s disease

Chlorpromazine can cause a condition that affects the heart rhythm (Qt prolonged). Prolonged Qt can rarely cause serious (rarely fatal) fast / irregular heartbeat and other symptoms (such as severe dizziness, unconsciousness) that require immediate medical attention.

If you have some medical conditions or QT prolonged other medications are taking Qt can increase the risk of prolonging. Before using Chlorpromazine, tell your doctor or pharmacist about all the medicines that you take and if you have any of the following conditions: Fixed heart problems (heart failure, slow heartbeats, EKG QT); Family history of some heart problems (Qt) EKG longevity, sudden cardiac death).

Lower levels of potassium or magnesium in the blood can also increase the risk of QT being long. This risk can increase if you use certain medications (such as diuretic / “water tablets”) or if you have conditions like severe sweating, diarrhea or vomiting. Talk to your doctor about using Chlorpromazine safely.

Chlorpromazine can make you dizzy or depress you or blur your vision. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution or clear vision. Avoid alcoholic beverages. If you are using marijuana, talk to your doctor.

Before using surgery or imaging procedures (such as some X-ray, CT scan), the use of contrast dye (like metrizamide) is required, tell your doctor or dentist that you are using this medicine and your use Regarding all the products to be done (including prescription drugs), nonprescription drugs and herbal products).

Chlorpromazine can make you more sensitive to the sun. Keep your time limited in the sun. Avoid Tanning Booths and sunlamps. Use sunscreen on the outside and wear protective clothing. Tell your doctor immediately if you burn in the sun or have blisters / redness on the skin.

Chlorpromazine can give you less sweat, which is more likely to cause heat stroke. Avoid doing things that can cause you to heat, such as hard work or exercise in hot weather, or using hot tub. When the weather is hot, drink lots of fluids and wear light clothes. If you heat more, then find a place to calm down and relax. If you do not have a fever, then seek medical help immediately after changes in mental / mood, headache, or dizziness.

Due to severe muscle problems during Chlorpromazine treatment, children with acute diseases (such as a viral infection, dehydration) increase the risk. Consult the doctor for more information.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, lighthouse, drowsiness, uncontrollable movements, and anticholinergic effects (such as constipation, difficulty urination and blurred vision), and QT prolongation (see above). The risk of drowsiness, dizziness, and lighthouse can increase.

During pregnancy, this drug should be used only when explicitly necessary. Avoid the use of Chlorpromazine near the due date because it can cause low blood pressure in the mother. The mothers who have used this drug during pregnancy rarely have a problem of liver, which involves having eyes yellowing / skin or deep urine. If you see liver problems in your infant, tell the doctor immediately. When this drug is used during the last 3 months of pregnancy, children born with these mothers can develop symptoms including muscle stiffness or stiffness, drowsiness, feeding / difficulty breathing, or constant crying. If you see any of these symptoms in your newborn especially in their first month, then tell the doctor immediately.

Since untreated mental / mood disorders (such as schizophrenia, mental disorder, bipolar disorder) can be a serious condition, do not stop taking this medicine until it is directed by your doctor. If you are planning a pregnancy, become pregnant, or think that you may be pregnant, discuss the benefits and risks of using this drug during pregnancy immediately with your doctor.

This medicine passes in breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.


Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that can interact with this drug include: alpha blockers (such as prazosin), anticholinergic/antispasmodic drugs (such as atropine,dicyclomine), drugs that increase the amount of dopamine in your body (such as cabergoline, levodopa, pergolide, ropinirole), lithium, guanethidine, warfarin.

Other medicines can affect the removal of chlorpromazine from your body, which can affect how chlorpromazine works. Examples include  pindolol, propranolol, drugs for treating seizures (such as phenobarbital, phenytoin), saquinavir, and others.

In addition to chlorpromazine, many medicines can affect cardiac rhythm (Qt) prolongation, including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (e.g erythromycin). Therefore, before using chlorpromazine, report all the medicines that you are currently using for your doctor or pharmacist.

If Chlorpromazine is taken with other products that can cause sleepiness or breathing problem, then the risk of serious side effects (such as slow / shallow inhalation, severe sleepiness / dizziness) can increase. Tell your doctor or pharmacist whether you are taking other products like opioid pain or cough relief (such as codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as  alprazolam, lorazepam, zolpidem), muscle relaxants Are there. carisoprodol,  cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the label on all your drugs (like allergy or cough-and-cold products), because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Chlorpromazine can interfere with certain laboratory tests (including some pregnancy tests, including phenylketonuria tests), which could possibly lead to false test results. Ensure that the lab staff and all your doctors know that you use this medicine.


If someone is treated and has serious symptoms such as difficulty in getting out or breathing, call 911. Otherwise, call the Poison Control Center immediately, American residents can call their local toxin control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: severe sleepiness / deep sleep, loss of consciousness, movement, restlessness, seizures, irregular heartbeats.


Do not share this medication with others.

Laboratory and / or medical tests (such as liver test, blood count, eye examination) should be periodically monitoring your progress or checking side-effects. Consult your doctor for more details.

Keep all medical and laboratory appointments.

Missed Dose

If you miss a dose, then as soon as you remember it, take it. If it is near the next dose time, then leave the thesis dose and set your normal dose. Do not double the dose to catch up.


Store at room temperature between 68-77 ° F (20-25 ° C) away from light and moisture. Brief storage is allowed between 59-86 degrees F (15-30 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Until instructed to do so, do not flush the medicines under the toilet or drain them in the drain. When this period expires or is not required, leave this product appropriately. Consult your drug dealer or local waste disposal company to get more information about safely terminating your product.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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