Anafranil Oral : Uses, Side Effects, Interactions


GENERIC NAME(S): Clomipramine


Clomipramine, sold under the brand name Anafranil among others. Anafranil is used to treat obsessive compulsive disorder (OCD). It helps in reducing frequent / unwanted thoughts (obsession), and it helps in reducing compulsions such as repetitive tasks (hand washing, counting, investigation) that interfere with daily life.

This drug is related to a class of drugs called tricyclic antidepressants. It works by restoring the balance of some natural substances (the serotonin among others) in the brain.

How To Use Anafranil

Before starting the Anafranil or Clomipramine, read the medication guide given by your pharmacist and every time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medicine with your doctor’s prescribed diet or without mouth. To reduce side effects such as stomach upset, Anafranil can be started on low dose, which is given in many doses during the day with food, and gradually increases because your body gets used to it. She goes. After reaching the best dose for you, the total dose can be taken once daily, usually at the time of sleeping during the day to stop drowsiness or as directed by your doctor. Generally, daily dose will not exceed 250 mg for adults and 200 mg for children and adolescents.

Follow your doctor’s instructions carefully. Do not take more or less medication or take more than prescribed. There will be no improvement in your situation and the risk of your side effects such as seizures can increase. Dosage is based on your medical condition and medical reaction.

Avoid drinking grapes or drinking grapes while treating this medicine unless your doctor gives you directions. Grapes can increase the amount of some medicines in your bloodstream. Contact your doctor or pharmacist for more information.

Use Anafranil regularly so that it can get the most benefit. If you feel OK continue to take it. To help you remember, use each day at the same time.

Do not stop taking this medicine without consultation with your doctor. Some conditions may get worse when the drug is stopped suddenly. If you stop taking this medicine suddenly, you may experience sweating, dizziness, nausea, vomiting, headache or irritability. Your dose may need to be gradually decreased.

It may take 2 to 3 weeks or more before paying attention to the full effect of this medication. Inform your doctor if your situation persists or if it worsens.

Side Effects

See also the warning section.

Dizziness, drowsiness, dry mouth, constipation, stomach bad, nausea, vomiting, changes in appetite / weight, flush, sweat, fatigue and blurred vision can occur. Symptoms of anxiety can temporarily deteriorate when you first begin taking Anafranil or Clomipramine. If any of these effects persists or worsens immediately, inform your doctor or pharmacist immediately.

To relieve dry mouth, suck hard candy or ice chips (sugar-free), chew gum (sugar-free), drink water or use the option of saliva.

To prevent constipation, maintain adequate diet in the fiber, drink plenty of water and exercise. If you get constipation while using this medicine, consult your pharmacist to help you choose a laxative (e.g., stimulant type with stool softener).

Remember that your doctor has prescribed this drug because he or she has decided that the benefit is higher than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor immediately if you have any serious side-effects, including: changes in mental / mood (e.g, confusion, depression, memory problems), increased / painful breast, production of unwanted breast milk, irregular / painful menstrual cycle, Muscle stiffness, ear ache, sexual problems (e.g, decrease in sexual capacity, changes in desire), numbness (shiver), numbness of hands / leg / rattling, urinating Problems, easily injury / bleeding, abnormal / uncontrolled motion (especially tongue / face / lips), severe stomach / stomach ache, deep urination, yellowing of eyes / skin.

Anafranil can increase serotonin and rarely cause a very serious condition, which is called serotonin syndrome / toxicity. The risk increases if you are taking other medicines which increase the serotonin, so tell your doctor or pharmacist about all the medicines that you take. Get medical help immediately when some of the following symptoms develop: Fast heartbeats, hallucinations, loss of coordination, severe dizziness, severe nausea / vomiting / diarrhea, muscle shaking, unexplained fever, abnormal movement or restlessness

If you have a very serious side effect, get medical help, including: black stool, chest pain, unconsciousness, slow / irregular heartbeats, visits, vomiting coffee grounds, eye pain / swelling / Redness, looks like wide pupils, vision changes (like watching the rainbow around the night lights).

A very serious allergic reaction to this drug is rare. However, if you see symptoms of a serious allergic reaction, get medical help, including: fever, swelling lymph nodes, rash, itching / swelling (especially the face / tongue / throat), severe dizziness, respiratory distress.

This is not a complete list of possible side effects. If you do not list other effects above, contact your doctor or pharmacist.

In America – Call your doctor for medical advice about side effects. You can notify the FDA of side effects on 1-800-FDA-1088 or

In Canada – Call your doctor for medical advice about side effects. You can report the health effects of Canada on 1-866-234-2345.


Before taking Anafranil or Clomipramine, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic  antidepressants  (e.g., imipramine,  nortriptyline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood problems (e.g., purpura, thrombocytopenia),   breathing problems (e.g., asthma, chronic bronchitis), personal or family history of glaucoma (angle-closure type), eating disorders (e.g., bulimia),   heart problems (e.g., arrhythmias, coronary artery disease, recent heart attack), intestinal problems (e.g., chronic constipation, ileus), liver problems, kidney problems, personal or family history of other mental/mood conditions (e.g., bipolar disorder, schizophrenia), history of hospitalization for a very serious reaction to certain medications(neuroleptic malignant syndrome), heartburn / stomach acid in the esophagus (e.g., due to hiatal hernia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (urinary retention, enlarged prostate), any condition that may increase your risk of seizures (e.g., alcohol/sedative dependency, use of electroconvulsive therapy,  brain injury/disease), certain types of tumors (e.g., pheochromocytoma,  neuroblastoma).

Anafranil may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Anafranil, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Lower levels of potassium or magnesium in the blood can also increase the risk of QT being long. If you use certain medications (such as diuretic / “water Pills”) or if you have a condition like severe sweating, diarrhea, or vomiting, then this risk may increase. Talk to your doctor about using Anafranil safely.

This medication can make you feel dizzy or flowing or temporarily blurred your vision. Alcohol or marijuana can make you more dizzy or deaf. Unless you can safely do it, do not drive, use machinery, or do anything that requires caution or clear vision. Limit alcoholic beverages. If you are using marijuana, talk to your doctor.

To diminish the dizziness and lightheadedness, rise slowly, while rising from the position of sitting or lying.

Before surgery, tell your doctor or dentist that you are taking this medicine.

Care is taken while using this drug in children participating in active sports, as it can increase the risk of heart problems. (See also the warning section.)

Older adults may be more susceptible to the side effects of this drug, especially bleeding, confusion, dizziness, and QT prolongation (see above).

This drug should be used only when explicitly required during pregnancy. During pregnancy newborn infants who have exposure to Anafranil may have symptoms of withdrawal or side effects. Tell your doctor immediately if you see anxiety, shock, feeding problem, fast breathing or touring in your newborn.

Since untreated mental / mood related problems (such as obsessive compulsive disorder, depression, panic attack) can be a serious condition, do not stop taking this medicine until your doctor prescribes it. If you are planning a pregnancy, become pregnant, or think that you may be pregnant, discuss the benefits and risks of using your medicine immediately during your pregnancy.

This medicine passes in breast milk and can have an undesirable effect on the nursing infant. Consult your doctor before breastfeeding.


See also section of usage

Drug interactions can change how your medicines work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescriptions / non-prescription medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change any drug supplements without the approval of your doctor.

Some products that interact with this drug include: anticholinergics (e.g., atropine, belladonna alkaloids, scopolamine), some medications for high blood pressure (e.g., clonidine, guanethidine), cisapride,  digoxin,   thyroid supplements, valproic acid, drugs that can cause bleeding/bruising (e.g., “blood thinners” such as warfarin/heparin, anti-platelet drugs including aspirin or NSAIDs such as ibuprofen).

Taking the MAO inhibitor with this drug can be a cause of serious (potentially fatal) drug interactions. During treatment with this drug, avoid taking the MAO inhibitor ((isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine). Most MAO inhibitors should not be taken for two weeks before and after treatment with this drug. Ask your doctor when to start or stop this medication.

If you are taking other medicines that increase serotonin then the risk of serotonin syndrome / toxicity increases. Examples include MDMA /”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as  fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Many drugs besides Anafranil may affect the heart rhythm (QT prolongation), including amiodarone,   dofetilide,   quinidine,  sotalol,   pimozide, procainamide, macrolide antibiotics (such as erythromycin), among others. Therefore, before using clomipramine, report all medications you are currently using to your doctor or pharmacist.

Other medications can affect the removal of Anafranil from your body, which may affect how Anafranil works. Examples include artemether/lumefantrine, barbiturates (such as phenobarbital),  cimetidine, haloperidol, certain drugs for heart rhythm (such as  flecainide/propafenone), certain HIV protease inhibitors (such as fosamprenavir), phenothiazines (such as thioridazine), certain anti-seizure drugs (such as phenytoin), terbinafine.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizinediphenhydramine), drugs for sleep or anxiety (such as  alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodolcyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone).

Carefully check the label of all prescriptions and non-prescription medicines including pain relief / fever prevention (NSAIDs such as aspirin, ibuprofen, naproxen) of many medicines, if taken together with this medicine, it can increase the risk for bleeding. . Low-dose aspirin, as your physician should be prescribed for specific medical reasons such as prevention of heart attack or stroke (usually at a diet of 81-325 mg per day). Contact your doctor or pharmacist for more information.

Check the label on all your drugs (e.g, cough-and-cold products) because they may include drowsiness or decongestants that can increase your heart rate or blood pressure. Ask about the safe use of those products from your pharmacist.

By drinking cigarettes, this blood level of the drug is reduced. Tell your doctor whether you smoke or if you have recently stopped smoking.

Over Dose

If someone is treated and has serious symptoms like having trouble going out or breathing, call 911. Otherwise, call the Poison Control Center immediately. US residents can call their local venom control center at 1-800-222-1222. Canadians can call a provincial poison control center. Symptoms of overdose may include: fast / irregular heartbeat, severe dizziness, unconsciousness, delirium, seizures, loss of consciousness.


Do not share this medication with others.

Laboratory and / or medical tests (e.g, EKG, liver function tests, blood count) can be done regularly to monitor your progress or examine side-effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, then as soon as you remember, take it. If it is near the next dose time, then leave the thesis supplement and start your normal dose program again. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Until instructed to do so, do not flush the medicines in the toilet and do not drain them. When this period expires or does not need it, then properly release this product. Consult your pharmacist or local waste disposal company.

Disclaimer: DrLinex has made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

Leave a Reply

Your email address will not be published. Required fields are marked *